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PI3K and AKT Isoforms in Immunity
This book provides an essential overview of the role of phosphoinositide-3-phosphate kinase (PI3K) isoforms in modulating the function of immune system cells and their involvement in disease. PI3K is a family of kinases involved in basic cellular processes such as proliferation, migration and cell death. Recent work has highlighted the multiple roles of PI3K classes and subunits and their involvement in the immune response to the body’s own and foreign antigens and diseases such as cancer and autoimmunity. This book offers a detailed introduction to the biology of the three PI3K classes, followed by an extensive discussion of the diverse roles of AKT and PI3K isoforms in immune cells. Based on this knowledge, it subsequently explains in more detail how specific isoforms are connected to immune-mediated diseases. The book concludes by highlighting the latest advances in the production of isoform-specific inhibitors and their use in various human diseases. This book is intended as a reference guide for students and researchers interested in the multifaceted aspects of PI3K biology.
Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases
This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune d...
Molecular Biochemical Aspects of Cancer
This book discusses the role of genes, oncogenes, anti-oncogenes, free radicals, PUFAs, anti-oxidants, lipid peroxidation process, telomere, and angiogenesis on the origin of cancer, cell proliferation, and cancer in general. It includes a broad introduction to cancer cells; genes, oncogenes, and anti-oncogenes; and free radicals. In later chapters, it discusses in depth the relationship among free radicals, lipid peroxidation and anti-oxidants in cell proliferation. It also discusses aerobic and anaerobic metabolism and their relationship to cancer, as well as the Warburg effect and its potential in the development of new targets for cancer management. Based on these and other evidences, Molecular Biochemical Aspects of Cancer introduces a novel concept that suggests that selective enhancement of free radical generation in tumor cells could form a strategy to induce apoptosis of cancer cells employing bioactive lipids. It presents a new method of treatment of cancer using in vitro, in vivo and clinical data. This book will interest oncologists, scientists, molecular biologists, life scientists.
T Cell Regulation by the Environment
Naïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, changing both phenotype and function. Differentiation into a specific subset depends on the nature of the antigen and of the environmental milieu. Notably, certain nutrients, such as vitamins A and D, sodium chloride, have been shown to modulate T cell responses and influence T cell differentiation. Parasite infection can also skew Th differentiation. Similarly, the gut microbiota regulates the development of immune responses. Lastly, the key role of metabolism on T cells has also been demonstrated. This series of articles highlights some of the multiple links existing between environmental factors and T cell responses.
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The T.I.G.E.R. Protocol
Auto-immune disorders like Graves Disease, Hashimoto's Thyroiditis, Lupus, Coeliac and even Long-Covid, affect an estimated 300 million people worldwide. These disorders can be frustrating as they are difficult to diagnose, painful and often invisible. Now, with this simple yet powerful 5-step plan devised by Dr Akil Palanisamy, readers can learn to treat, tame and potentially reverse painful autoimmune conditions. In The T.I.G.E.R. Protocol, Dr Akil Palanisamy uses his training in Western medicine and complementary therapies to create an integrative approach to treat autoimmune diseases. Addressing five key elements - Toxins, Infections, Gut health, Eating right and Rest and balance - this ...
Vegetation of the Canary Islands
The volcanic and oceanic nature of the Canary Islands, its rich plant biodiversity and high rate of endemism, as well as the relict character of some of its plant communities make it a territory of great biological interest. The main geographic, climatic, bioclimatic, biogeographic and floristic features of the Islands are shown and related to the distributional pattern of potential communities along an altitudinal gradient. Current vegetation units and their ecology are described and illustrated with numerous pictures. Potential vegetation units are summarized and comprehensive maps of the potential natural vegetation for each island are given. Human impact on the natural landscape, the occurrence of invasive plants, and the probable impact of climate change on the flora and vegetation are discussed. The conservation status of flora and vegetation are assessed. Four appendixes include a syntaxonomical scheme, a brief history of botanical studies and explorations in the Islands, ethnobotanical notes, and a list of selected literature.
