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Novel clinical applications of extracellular vesicles
During the last years, the research on extracellular vesicles (EVs) has raised giving new insights into pathophysiology of several diseases. EVs are membrane-bound particles secreted by almost all cell types. Depending on their biogenesis and size they include exosomes, microparticles / microvesicles and apoptotic bodies. Characteristically, EVs carry markers from the source cell membrane and contain genetic material, lipids and proteins inside. They are known to play a role in cell-to-cell communication and to produce genotypic and phenotypic modifications in the target cell including: antigen presentation, apoptosis induction, cellular activation, inhibition or differentiation. In particul...
Inflammation, Aging, and Oxidative Stress
The book describes the major degenerative processes and pathologies exacerbated by senescence and how they can be alleviated through retardation of cellular aging. Topics discussed include neurodegenerative disease, protein oxidation, cerebrovascular disease, particle-induced inflammation and cardiovascular disease, Alzheimer’s disease, ovarian aging, dietary and endogenous anti-oxidants in management of Parkinson’s disease, and effects of exercise on oxidation and inflammation. The nineteen expertly authored chapters are organized into three sections in order to present a complete picture to the reader: Age Related Cellular Events, Role of Inflammatory and Oxidative Processes in Age-Rel...
Essential Aspects of Immunometabolism in Health and Disease
Immunometabolism has emerged as an intersectional crossroad between metabolism and immune response. Over the past decade, it has become clear that most - if not all - immune cell functions are not separated from cellular metabolism. Although seminal works have addressed the metabolic fate of immune cells during differentiation and function, the physiological status of a given tissue is also dependent on the cell metabolism. The dialogue between immune cells and their microenvironment can also modulate cellular metabolism, which can trigger the onset and progression of a multitude of inflammation-mediated diseases. Thus, uncovering the specific characteristics of the metabolism in different i...
Mitochondrial Communication in Physiology, Disease and Aging
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
The Origins of Self
The Origins of Self explores the role that selfhood plays in defining human society, and each human individual in that society. It considers the genetic and cultural origins of self, the role that self plays in socialisation and language, and the types of self we generate in our individual journeys to and through adulthood. Edwardes argues that other awareness is a relatively early evolutionary development, present throughout the primate clade and perhaps beyond, but self-awareness is a product of the sharing of social models, something only humans appear to do. The self of which we are aware is not something innate within us, it is a model of our self produced as a response to the models of us offered to us by other people. Edwardes proposes that human construction of selfhood involves seven different types of self. All but one of them are internally generated models, and the only non-model, the actual self, is completely hidden from conscious awareness. We rely on others to tell us about our self, and even to let us know we are a self.
The Journal of Cell Biology
No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-
La atención temprana. Un compromiso con la infancia y sus familias
El desarrollo infantil es entendido, en la actualidad, como el resultado de múltiples interacciones de diferentes factores como son los biológicos, psicológicos y los socio-culturales que se desencadenan y se llevan a cabo en el marco de los distintos contextos de vida, entre los que ocupa un lugar primordial e imprescindible la familia. La atención temprana ha podido beneficiarse de las aportaciones que, desde los diferentes campos del saber y desde distintos marcos explicativos, han ampliado el conocimiento de lo que es un bebé y de lo que éste necesita para desarrollarse. Desde una perspectiva interdisciplinar que asegura distintas miradas y sensibilidades, el libro pretende ofrecer un acercamiento a la concepción y práctica de la atención temprana, centrada en la familia como motor de desarrollo, que incorpore tanto cuestiones relativas a sus fundamentos, organización e intervención como los nuevos retos derivados de los avances de las ciencias y de la investigación.
The Valentine & Catharine Hoh/Hay Family in America
Ancestors and descendants of John Valentine Hay (Johann Valentin Hoh) (1745-1813?), who was born in Mittelbrunn, Palatinate, Germany, a son of Johann Valentin Hoh and Maria Margaretha Montzinger. He married Catharine about 1798 in Bedford Co., Pennsylvania. She was born ca. 1776/80 in Pennsylvania, died before 1856 in Blair Co., Pa. He died before 1813 in Morrisons Cove, Woodberry Twp., Bedford Co., Pa. They had five children, all born in Morrisons Cove. Descendants live in Pennsylvania, Ohio, Kansas, Illinois, Iowa, Missouri, Nebraska, California and elsewhere.
Zweibrücker Zeitung
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