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Mechanisms underlying firing in healthy and sick human motoneurons
Since the latter half of the twentieth century an enormous amount of knowledge about mammalian motoneuron pools has been collected. This progress was enabled mostly by the development of the precise techniques of intracellular recordings in acute animal experiments, many of which were conducted under deep anaesthesia. Recently obtained evidence indicates that anaesthetics used at that times changed certain properties of the cell membrane, which might affect firing of the neuron. Experiments on normal humans gets around this problem, which lets one compare MN firing characteristics in humans and reduced preparations. Firing pattern of human motoneurons is obtained indirectly by recording from...
Structure-Related Intrinsic Electrical States and Firing Patterns of Neurons With Active Dendrites
Activity of the multi-functional networked neurons depends on their intrinsic states and bears both cell- and network-defined features. Firing patterns of a neuron are conventionally attributed to spatial-temporal organization of inputs received from the network-mates via synapses, in vast majority dendritic. This attribution reflects widespread views of the within-cell job sharing, such that the main function of the dendrites is to receive signals and deliver them to the axo-somatic trigger zone, which actually generates the output pattern. However, these views are now revisited due to finding of active, non-linear properties of the dendritic membrane practically in neurons of practically a...
Information Technologies in Biomedicine
This book constitutes the refereed proceedings of the 4th International Conference on Information Technologies in Biomedicine, ITIB 2012, held in Goglin, Poland, in June 2012. The 60 revised full papers were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on image analysis; signal processing; biocybernetics; biomaterials; bioinformatics and biotechnology; biomechanics and rehabilitation; assisted living systems.
Optical Methods, Sensors, Image Processing, and Visualization in Medicine
Proceedings of SPIE present the original research papers presented at SPIE conferences and other high-quality conferences in the broad-ranging fields of optics and photonics. These books provide prompt access to the latest innovations in research and technology in their respective fields. Proceedings of SPIE are among the most cited references in patent literature.
Practical Biomedical Signal Analysis Using MATLAB
Practical Biomedical Signal Analysis Using MATLAB presents a coherent treatment of various signal processing methods and applications. The book not only covers the current techniques of biomedical signal processing, but it also offers guidance on which methods are appropriate for a given task and different types of data.The first several chapters o
Applications of Rehabilitation Engineering Technologies for the Intervention of Neural and Motor Impairment Post Stroke
Stroke is the leading cause of disability worldwide. Stroke survivors often have motorimpairments which contribute to upper limbs dysfunctions, reduced balance, posturalcontrol and reduced mobility and proprioception. These physical symptoms lead toreduced social participation and poor quality of life. Over the past ten years, therehad been an enormous focus on the use of virtual reality (VR) and other technologiesto improve clinical outcomes for people with stroke. These technologies includelarge scale bespoke manufactured immersvie virtual reality system, or home basedrehabilitation device such as the commercially available device Nitendo Wii andMicrosoft XBox. The clinical efficacy of the...
The Role of Mitochondria, Oxidative Stress and Altered Calcium Homeostasis in Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Treatments
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, devastating and fatal disease characterized by selective loss of upper and lower motor neurons of the cerebral cortex, brainstem, spinal cord and muscle atrophy. In spite of many years of research, the pathogenesis of ALS is still not well understood. ALS is a multifaceted genetic disease, in which genetic susceptibility to motor neuron death interacts with environmental factors and there is still no cure for this deleterious disease. At present, there is only one FDA approved drug, Riluzole which according to past studies only modestly slows the progression of the disease, and improves survival by up to three months. The sufferin...
Biomechanics VII
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