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Tumor Metabolome Targeting and Drug Development
In this volume, the major metabolic alterations identified in cancer and tumor-associated cells are explored, including discussions of former and emerging approaches to drug development in targeting cancer cell metabolism. The metabolic network in cells promotes the generation of both energy and biomass needed for them to grow, divide and differentiate. However, the metabolism of malignant cells generally varies from that of normal cells. These differences provide a platform for the discovery of new approaches to targeting potential vulnerabilities in cancer cells for therapeutic options Some of the significant changes that occur involve ATP production and consumption that modulates the ATP to ADP ratio, hypoxia and the effects of reactive oxygen species on glycolysis, regulation of mitochondrial respiration, induction and suppression of autophagy, and the Warburg effect and “reverse” Warburg effect--these topics and more are discussed in this volume.
Advances in Epithelial Ovarian Cancer: Model Systems, Microenvironmental Influences, Therapy, and Origins
This eBook provides a compendium of the current state-of-the-art in research tools for, and understanding of, the critical research areas in epithelial ovarian cancer (EOC) with a strong emphasis on (HG-SOC). Research areas covered include therapy response and development, microenvironmental influences and the etiology and progression of EOC. Ten articles detail established and novel in vivo and in vitro model systems. These include primary and immortalized cell culture in 2D and 3D as well as genetically engineered, transgenic, spontaneous, syngeneic, classical xenograft and patient derived xenograft mouse models. The generation of genetically engineered mouse models of HG-SOC has been a ma...
Anticancer Research
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Cancer Research
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Tumor Cell Metabolism
The four sections of this book cover cell and molecular biology of tumor metabolism, metabolites, tumor microenvironment, diagnostics and epigenetics. Written by international experts, it provides a thorough insight into and understanding of tumor cell metabolism and its role in tumor biology. The book is intended for scientists in cancer cell and molecular biology, scientists in drug and diagnostic development, as well as for clinicians and oncologists.
Against Nihilism
Described by Thomas Mann as "e;brothers in spirit, but tragically grotesque companions in misfortune,"e; Nietzsche and Dostoevsky remain towering figures in the intellectual development of European modernity. Maia Johnson-Stepenberg's accessible new introduction to these philosophers compares their writings on key topics such as criminality, Christianity, and the figure of the "e;outsider"e; to reveal the urgency and contemporary resonance of their shared struggle against nihilism. Against Nihilism also considers nihilism in the context of current political and social struggles, placing Nietzsche and Dostoevsky's contributions at the heart of important contemporary debates regarding community, identity, and meaning. Inspired by class discussions with her students and aimed at first-team readers of Nietzsche and Dostoevsky, Against Nihilism provides an accessible, unique comparative study of these two key thinkers.
