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Systems Biology
This second edition volume expands on the previous edition with discussions of the latest advancements and methods used by scientists to study systems biology. The chapters in this book are organized into four parts. Part One looks at models in systems biology and parameters identification such as short peptide analysis, metastasis models, and metabolomics. Part Two covers computational methods in the study of organisms, and cancer non-linear dynamics. Part Three discusses critical transition states across Waddington’s like landscapes such as understanding cell differentiation through single-cell approaches and modeling mammary organogenesis from biological first principles. Part Four talk...
Approaching Complex Diseases
This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor eff...
The New Alchemists
Fifteen years after the first genetically modified (GM) seeds and food, only four GM plants have achieved significant market positions: corn, cotton, rapeseed and soybeans. Most of the other new constructs have caused unsolved problems or are only at the project stage, demonstrating the complexity of the task facing biotech companies. Doubts are also emerging about the real economic and agronomic benefits of genetically modified organisms. Little is known about their potential for upsetting environmental biodiversity in an irreversible way. Worries about their impact on human health have not been dispelled but have increased with the evident incapacity of current international standards to e...
Everything Flows
"The majority of the papers herein originated at the workshop 'Process Philosophy of Biology' ... held in Exeter in November 2014."--Page vii.
Systems Biology in Cancer Research and Drug Discovery
Systems Biology in Cancer Research and Drug Discovery provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology (i) in understanding aberrant signaling in cancer (ii) in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways (iii) in unwinding microRNAs complexity and (iv) in anticancer drug discovery and in clinical trial design. This book reviews the state-of-the-art knowledge and touches upon cutting edge newer and improved applications especially in the area of network modeling. It is aimed at an audience ranging from students, academics, basic researcher and clinicians in cancer research. This book is expected to benefit the field of translational cancer medicine by bridging the gap between basic researchers, computational biologists and clinicians who have one ultimate goal and that is to defeat cancer.
Personalized Medicine in the Making
This book offers a multidisciplinary look at the much-debated concept of “personalized medicine”. By combining a humanistic and a scientific approach, the book builds up a multidimensional way to understand the limits and potentialities of a personalized approach in medicine and healthcare. The book reflects on personalized medicine and complex diseases, the relationship between personalized medicine and the new bio-technologies, personalized medicine and personalized nutrition, and on some ethical, political, economic, and social implications of personalized medicine. This volume is of interest to researchers from several disciplines including philosophy, bio-medicine, and the social sciences. Chapter 16, “The Impact of Fantasy” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Confessions of an Illuminati, Volume III
Zagami pushes the boundaries once again with this unique and personal journey into the mysteries of the secretive world of the Dark Cabal. In the third book of this acclaimed series, Zagami explores a variety of cryptic topics that are always verified with documentation. This is not a work of fiction, but a tool with which readers can comprehend topics that range from the truth about the mythical Knights Templars to the Jesuits and their Vatican espionage game. Zagami uncovers the most credible candidates of the Grail mystery with proven testimony from an official saint of the Catholic Church. Zagami also upholds what he calls "conspiracy reality," a way to fight back against the system of lies and deceit responsible for the rise of Satanism in the Vatican, showing in the process the magical practices of the Illuminati.
Integrating Human Health into Urban and Transport Planning
This volume brings together the world’s leading experts on urban and transport planning, environmental exposures, physical activity, health and health impact assessment to discuss challenges and solutions in cities. The book provides a conceptual framework and work program for actions and outlines future research needs. It presents the current evidence-base, the benefits of and numerous case studies on integrating health and the environment into urban development and transport planning. Within cities there is a considerable variation in the levels of environmental exposures such as ambient air pollution, noise, and temperature, green space availability and physical activity. Many of these ...
The macrobiotic sect
Five years of investigation by various Italian police forces have thrown light on a mysterious sect present throughout the country and abroad. Known to many as Un Punto Macrobiotico, it is an association recognised by the Italian Ministry of Solidarity for its benevolent social activity. But it was later accused of criminal conspiracy resulting in modern-day slavery and the hidden recycling of enormous amounts of money. But who is Mario Pianesi, guru and absolute boss of that psycho-sect? How did he create his own personality cult and an impressive personal fortune? How does the psycho-sect work? How was it born? How has it evolved? The author, who lived within this group for 25 years, gives...
Occult Imperium
Christian Giudice's Occult Imperium explores Italian national forms of Occultism, chiefly analyzing Arturo Reghini (1878-1946), his copious writings, and Roman Traditionalism. Trained as a mathematician at the prestigious University of Pisa, Reghini was one of the three giants of occult and esoteric thought in Italy, alongside his colleagues Julius Evola (1898-1974) and Giulian Kremmerz (1861-1930). Using Reghini's articles, books, and letters, as a guide, Giudice explores the interaction between occultism, Traditionalism, and different facets of modernity in early-twentieth-century Italy. The book takes into consideration many factors particular to the Italian peninsula: the ties with avant-garde movements such as the Florentine Scapigliatura and Futurism, the occult vogues typical to Italy, the rise to power of Benito Mussolini and Fascism, and, lastly, the power of the Holy See over different expressions of spirituality. Occult Imperium explores the convergence of new forms of spirituality in early twentieth-century Italy.
