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Redox and Nitrosative Signaling in Cardiovascular System: from Physiological Response to Disease
The role of ROS/RNS signaling in cardiovascular functions and diseases is increasingly emerging in the last decades. The involvement of ROS/RNS in the control of a large number of cardiovascular functions like the regulation of the vascular tone, the control of blood pressure or myocyte excitation-contraction coupling and force development has been broadly investigated and in part clarified. On the other hand, many efforts have been focused in clarifying the redox mechanisms involved in cardiovascular diseases like ischemia/reperfusion injury, diabetes-associated cardiovascular dysfunctions, atherosclerosis or hypertension, just to mention the major ones. However, in most cases the two level...
Physiological and Pathological Role of ROS: Benefits and Limitations of Antioxidant Treatment
ROS were long considered one of the key players in tissue injury. Indeed, overproduction of ROS results in oxidative stress, a process leading to the development of many pathological conditions. For the treatment of these conditions, the use of antioxidants was proposed. Over time, it was shown that ROS at low concentrations act as signaling molecules, leading to the regulation of physiological functions. Moreover, several interventions that increase ROS generation activate stress-adaptive responses that extend the lifespan. It was also shown that excessive use of antioxidants can counter the beneficial effects of ROS. Currently, much progress has been made in understanding the role of ROS i...
Computational and Experimental Approaches in Multi-target Pharmacology
The next frontier in pharmacology is the development of multi-target strategies in which pathological processes are controlled by pharmacologically manipulating them at many different points at once. Designing multi-target strategies will require deep understanding of the complex physiology that underlies pathological processes. It will also require the development of single drugs with multiple targets, or combinations of drugs with compatible pharmacokinetics that work synergistically to maximize desirable effects while minimizing unwanted side effects. This e-Book contains ten original articles, each addressing a different aspect of this challenge. Together they open new perspectives and show the way forward in the development of multi-target therapeutics.
Chemical Abstracts
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CRC Handbook of Organic Photochemistry and Photobiology
This title includes research from experts in organic chemistry & many other disciplines. There are sections on new terminology, the usefulness of particular reactions & experimental details.
Neuromodulation
Neuromodulation will be the first comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. This book provides a complete discussion of the fundamental principles of neuromodulation and therapies applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs. The textbook is highly structured and organized into overarching sections that cover chronic pain, movement disorders, psychiatric disorders, epilepsy, functional electrical stimulation, cardiac, gastrointestinal, genitourinary and organ neuromodulation. The fundamental principles of electricity and infusion, neural tissue interface, biomedical engineer...
Storia d’impresa e imprese storiche. Una visione diacronica
Dopo aver messo a confronto le energie vitali, ingegnose e operose del nostro paese, e i privilegi, i favori, i protezionismi, che ne hanno inibito l’affermazione e ne hanno distorto lo sviluppo, il volume si focalizza sui fattori chiave in grado di spieg
Stati Generali del Patrimonio Industriale. 2022
L’Associazione Italiana per il Patrimonio Archeologico Industriale (AIPAI), in occasione dei suoi 25 anni, ha promosso i Secondi Stati Generali del Patrimonio Industriale. Per tracciare un bilancio ed elaborare strategie e visioni ha posto le condizioni per l’incontro tra gli addetti ai lavori e il confronto tra i molteplici ambiti operativi, di ricerca e istituzionali coinvolti. Ci si è riuniti a Roma e a Tivoli con la consapevolezza che il primo lascito dell’età industriale siamo noi, la nostra società con i suoi pregi e le sue contraddizioni, le incredibili conquiste degli ultimi secoli. La risposta è stata ampia e tra i numerosi contributi presentati in questo volume, si posson...
