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Modular Protein Domains
Since the full functionality of any given protein can only be understood in terms of its interaction with other, often regulatory proteins, this unique reference source covers all relevant protein domains, including SH2, SH3, PDZ, WW, PTB, EH, PH and PX. Its user-oriented concept combines broad coverage with easy retrieval of essential information, and includes a special section on Web-based tools and databases covering protein modules and functional peptide motifs. Essential for the study of protein-protein interactions in vivo or in silico, and a prerequisite for successful functional proteomics studies. With a prologue by Sir Tom Blundell.
Tropomyosin
A recent review of one of my grant applications commented on the ‘rediscovery of tropomyosin’. I was tempted to write back in my rebuttal to the reviewer that I didn’t realise it had been lost. Uncharacteristic maturity prevailed and I resisted the temptation, but I was struck by the underlying observation that research on the str- ture and function of tropomyosin has been somewhat invisible, particularly in terms of the cytoskeleton isoforms. So, how can it be that one of the two major components of the actin filament has been so thoroughly overlooked? I suspect that the answer is disappointingly pedestrian. Whereas the biochemistry of the 1980s revealed the potential of tropomyosin i...
The Birds, the Bees and the Platypuses
Michael Gross has been writing about science full time for the last eight years and as a night time hobby for the previous seven. From his treasure troves, he now presents his favourite science stories from these 15 years. What are the attractions that make him revisit a topic or reread an article again and again? Often, it's the sheer craziness of wildly unexpected findings or grotesquely oversized challenges. In other stories, there is a sexy element or an unexpected insight into the human condition. And sometimes, when reporting new and future technologies, the author just can't help thinking: >cooooooool!
Biochemistry of Smooth Muscle Contraction
This valuable resource provides a systematic account of the biochemistry of smooth muscle contraction. As a comprehensive guide to this rapidly growing area of research, it covers the structure and characteristic properties of contractile and regulatory proteins, with special emphasis on their predicted function in the live muscle. Also included in this book are intermediate filament proteins, and desmin and vimentin, whose function in smooth muscle is unknown; and several enzymes involved in the phosphorylation-dephosphorylation of contractile and other proteins.
Essential Readings in Biosemiotics
Synthesizing the findings from a wide range of disciplines – from biology and anthropology to philosophy and linguistics – the emerging field of Biosemiotics explores the highly complex phenomenon of sign processing in living systems. Seeking to advance a naturalistic understanding of the evolution and development of sign-dependent life processes, contemporary biosemiotic theory offers important new conceptual tools for the scientific understanding of mind and meaning, for the development of artificial intelligence, and for the ongoing research into the rich diversity of non-verbal human, animal and biological communication processes. Donald Favareau’s Essential Readings in Biosemiotic...
Cell Biology
This four-volume laboratory manual contains comprehensive state-of-the-art protocols essential for research in the life sciences. Techniques are presented in a friendly step-by-step fashion, providing useful tips and potential pitfalls. The important steps and results are beautifully illustrated for further ease of use. This collection enables researchers at all stages of their careers to embark on basic biological problems using a variety of technologies and model systems. This thoroughly updated third edition contains 165 new articles in classical as well as rapidly emerging technologies. Topics covered include: Cell and Tissue Culture: Associated Techniques, Viruses, Antibodies, Immunocyt...
The Codes of Life
Building on a range of disciplines – from biology and anthropology to philosophy and linguistics – this book draws on the expertise of leading names in the study of organic, mental and cultural codes brought together by the emerging discipline of biosemiotics. The volume represents the first multi-authored attempt to deal with the range of codes relevant to life, and to reveal the ubiquitous role of coding mechanisms in both organic and mental evolution.
Protein-Lipid Interactions
In 17 contributions by leading research groups, this first comprehensive handbook in the field covers the interactions between proteins and lipids that make the fabric of biological membranes from every angle. It examines the relevant hermodynamic and structural issues from a basic science perspective, and goes on to discuss biochemical and cell biological processes. The book covers physical principles as well as mechanisms of membrane fusion and fission. Additionally, chapters on bilayer structure and protein-lipid interactions as well as on how proteins shape lipids and vice versa, membrane penetration by toxins, protein sorting, and allosteric regulation of signal transduction across membranes make this a valuable information source for researchers in academia and industry.
