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Oligonucleotides diffuse poorly through biological barriers, including cell membranes. They are also rapidly degraded in vivo by nucleuses. Aiming to improve the administration of compounds, the book studies the development of nucleotide chemistry.
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In unserem Blick zurück in die Geschichte spielen nicht nur in der Schweiz, sondern rund um den Globus Männer die Hauptrolle. Von Frauen ist selten die Rede, hauptsächlich, weil ihre Rolle in patriarchalischen Gesellschaften nicht öffentlich sichtbar wurde, zum Teil, weil die Geschichtsschreibung sich wenig für sie interessierte. Dabei gab es auch in der Schweiz Frauen, welche die Gesellschaft aktiv mitgestalteten: mutig, unabhängig, selbstverantwortlich, unternehmerisch. Sie alle waren Pionierinnen ihrer Zeit. Und jede von ihnen hat Spuren in der Schweiz von heute hinterlassen – ob als Journalistin, Wissenschaftlerin, Unternehmerin, Künstlerin, Frauenrechtlerin oder einfach als starke Persönlichkeit. Mit Beiträgen von Sibylle Egloff, Simone Hofer, Simon Hurst, Verena Parzer Epp, Lukas Rühli, Marco Salvi, Patrik Schellenbauer, Barbara Stolba, Susanne Stortz, Claudia Wirz
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Expanded to twice as many entries as the 1985 edition, and updated with new publications, new editions of previous entries, titles missed the first time around, more of the artists' own writings, and monographs that deal with significant aspects or portions of an artist's work though not all of it. The listing is alphabetical by artist, and the index by author. The works cited include analytical and critical, biographical, and enumerative; their formats range from books and catalogues raisonnes to exhibition and auction sale catalogues. A selection of biographical dictionaries containing information on artists is arranged by country. Annotation copyrighted by Book News, Inc., Portland, OR
The chemistry of nucleosides and nucleic acids is a rapidly developing field. Many of the most important recent advances in medicinal chemistry have occured in this field with the development of novel nucleoside– and nucleotide–based antiviral and antitumor drugs. New synthesis strategies involving novel protecting groups have helped spur progress in drug–development and genome–sequencing research. This volume, comprised of contributions written by internationally recognized experts, covers cutting–edge developments in current nucleoside and nucleic acid research. The most recent synthesis innovations, including combinatorial approaches, spectroscopy and structural studies, thermodynamic and computational investigations, stability assessments, and medicinal applications are presented. Synthetic, physical, organic, bioorganic, and medicinal chemists working on all aspects of nucleoside and nucleic acid research will value this comprehensive state–of–the–art overview.