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Single-Cell-Based Models in Biology and Medicine
Aimed at postgraduate students in a variety of biology-related disciplines, this volume presents a collection of mathematical and computational single-cell-based models and their application. The main sections cover four general model groupings: hybrid cellular automata, cellular potts, lattice-free cells, and viscoelastic cells. Each section is introduced by a discussion of the applicability of the particular modelling approach and its advantages and disadvantages, which will make the book suitable for students starting research in mathematical biology as well as scientists modelling multicellular processes.
Rowe V. Pacific Quad, Inc.
In this deposition skills file, Alice Rowe has brought an action under Title VII of the 1964 Civil Rights Act and the Nita Fair Employment Act (which is identical to the California Fair Employment & Housing Act) for sexual harassment and wrongful discharge against her employer, Pacific Quad, Inc. She asserts that her supervisor, operations manager Stanley Schmit, continually leered at her, made offensive sexually suggestive comments to her, brushed by her in order to sexually touch her, and, finally, propositioned her during the two weeks she worked for Pacific Quad. She further alleges that the president of Pacific Quad, John Walsh, was informed of the harassment and ratified it. Rowe claim...
Organogenesis in Development
Understanding organogenesis is central to current efforts to direct stem cell differentiation and function in the context of a complex organ. Defects in organogenesis are often the major manifestations of human genetic disease syndromes. This volume describes the development of 10 major organ systems, reviewed by experts in each, to provide an up-to-date overview for researchers within and outside the field, students, teachers and clinicians. - Summarizes the key morphological and cellular events - Emphasizes up-to-date research relating to molecular control mechanisms - Draws on a range of model vertebrates and contemporary experimental approaches, including lessons learnt from human developmental disease - Distils common themes and differences for comparative studies - Highlights key remaining questions and sets the agenda for future research
Algebraic Aspects of Integrable Systems
A collection of articles in memory of Irene Dorfman and her research in mathematical physics. Among the topics covered are: the Hamiltonian and bi-Hamiltonian nature of continuous and discrete integrable equations; the t-function construction; the r-matrix formulation of integrable systems; pseudo-differential operators and modular forms; master symmetries and the Bocher theorem; asymptotic integrability; the integrability of the equations of associativity; invariance under Laplace-darboux transformations; trace formulae of the Dirac and Schrodinger periodic operators; and certain canonical 1-forms.
SIDE III
This volume contains the proceedings of the third meeting on ``Symmetries and Integrability of Difference Equations'' (SIDE III). The collection includes original results not published elsewhere and articles that give a rigorous but concise overview of their subject, and provides a complete description of the state of the art. Research in the field of difference equations--often referred to more generally as discrete systems--has undergone impressive development in recent years. In this collection the reader finds the most important new developments in a number of areas, including: Lie-type symmetries of differential-difference and difference-difference equations, integrability of fully disc...
A Systems Biology Approach to Blood
The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels. A Systems Biology Approach to Blood is divided into three main sections: basic compo...
Multiscale Modeling of Developmental Systems
Mathematical and computational biology is playing an increasingly important role in the biological sciences. This science brings forward unique challenges, many of which are, at the moment, beyond the theoretical techniques available. Developmental biology, due to its complexity, has lagged somewhat behind its sister disciplines (such as molecular biology and population biology) in making use of quantitative modeling to further biological understanding. This volume comprises work that is among the best developmental modeling available and we feel it will do much to remedy this situation.This book is aimed at all those with an interest in the interdisciplinary field of computer and mathematic...
Sex Determination and Sexual Development
This volume reviews our current understanding for how sex determination is initiated and how it results in sexual dimorphic development. Chapters discussing work on different model systems provide a basis for understanding similarities that exist between different species. Coverage includes discussion of sexual development of the soma in C. elegans; sexual development of the germline in C. elegans; sexual development of the soma in Drosophila; sexual development of the germline in Drosophila; sexual development of the soma in the mouse; sexual development of the germline in the mouse; control of sex-specific behavior in Drosophila; and control of sex-specific behavior in vertebrates. - Uncovers the latest research findings on sexual determination and sexual development - Model systems illustrate key sexual similarities - Explores in-depth the origins of sex specific behavior
Transcriptional Switches During Development
This new volume in the Current Topics in Developmental Biology series concentrates on transcriptional switches during development. It includes chapters on such topics as muscle diversity, transcriptional response to genome structural variation, and the temporal gene network in Drosophila neural stem cells. With an international team of authors, this volume is a must-have addition for researchers and students alike. - Concentrates on transcriptional switches during development - Includes chapters on such topics as muscle diversity, transcriptional response to genome structural variation, and the temporal gene network in Drosophila neural stem cells - With an international team of authors, this volume is a must-have addition for researchers and students alike
