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Identifying Novel Inborn Errors of the Immune System
In her study Elisabeth Salzer describes three novel monogenic diseases. For CD27 deficiency Elisabeth Salzer describes a large cohort of patients. Although all patients shared the same causative missense mutation, they displayed diverse clinical presentations. In another patient she was able to identify a mutation in PRKCD resulting in a primary immunodeficiency with severe Lupus-like autoimmunity. The patient exhibited increased mRNA levels of IL6. Therefore, treatment with Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody was suggested. In a family with a history of deaths due to inflammatory bowel disease she identified a missense mutation in IL21. She produced wild type and mutated IL-21 protein and demonstrated a loss of function phenotype. As IL-21 is in clinical trials, she proposed a potentially curative treatment option. These discoveries contributed to the understanding of the multifaceted regulatory mechanisms of the immune system and highlighted essential players in these complex signaling networks.
Molecular Mechanisms of Signal Transduction
This book contains overviews of topics that have been discussed. It includes contributions from leading experts in the field on small GTPases, protein kinesis, receptors and transcription factors. A particular focus was the influence of oxygen radicals on signalling processes. It also contains the contributions of scientists early in their career, who have made an excellent contribution to the institute.
Plants and Microclimate
A STUDY OF PLANTS-CLIMATE AND THE IMPACTS OF CHANGE UPON VEGETATION.
Pediatric Stem Cell Transplantation
This textbook examines stem cell transplatation in pediatric patients.
Green Business Process Management
Green Business Process Management – Towards the Sustainable Enterprise" consolidates the global state-of-the-art knowledge about how business processes can be managed and improved in light of sustainability objectives. Business organizations, a dominant part of our society, have always been a major contributor to the degradation of our natural environment, through the resource consumption, greenhouse emissions, and wastage production associated with their business processes. In order to lessen their impact on the natural environment, organizations must design and implement environmentally sustainable business processes. Finding solutions to this organizational design problem is the key...
A New Generation of High-Power, Waveform Controlled, Few-Cycle Light Sources
This thesis presents first successful experiments to carrier-envelope-phase stabilize a high-power mode-locked thin-disk oscillator and to compress the pulses emitted from this laser to durations of only a few-optical cycles. Moreover, the monograph introduces several methods to achieve power-scalability of compression and stabilization techniques. All experimental approaches are compared in detail and may serve as a guideline for developing high-power waveform controlled, few-cycle light sources which offer tremendous potential to exploit extreme nonlinear optical effects at unprecedentedly high repetition rates and to establish table-top infrared light sources with a unique combination of brilliance and bandwidth. As an example, the realization of a multi-Watt, multi-octave spanning, mid-infrared femtosecond source is described. The thesis starts with a basic introduction to the field of ultrafast laser oscillators. It subsequently presents additional details of previously published research results and establishes a connection between them. It therefore addresses both newcomers to, and experts in the field of high-power ultrafast laser development.
