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Stem Cells
Stem cells are relatively undifferentiated cells which are the permanent lineage ancestor cells of tissues. Newly developed molecular biological techniques and probes have made possible dramatic advances in our ability to study the lineage development of stem cells. A major impetus to develop these techniques has been to identify specific stem cells for gene therapy purposes. The role that stem cells play in the development of cancer is also an important area. This book provides up-to-date reviews on a wide variety of stem cell systems by world experts. Chapters range from descriptions of the current knowledge of the biology of stem cells, to current molecular biological approaches and clinical implications. Oncologists and cell biologists will find this book of particular interest. It will also be usefule to radiobiologist, biotechnologists, and gene therapists. - Provides reviews of stem cell systems by world experts - Covers stem cell biology in plants, invertebrates, and mammals - Presents clinical implications of stem cell differentiation
New Aspects in the Diagnosis and Treatment of Hodgkin’s Disease
In the field of Hodgkin's lymphoma, many new data have been collected during the last decade both on the cell of origin of this disease and on more effective therapies to cure the majority of pa tients even in the advanced stages. Therefore, it seems to be justi fied to compile these new data in a special volume of Recent Re sults in Cancer Research. This volume summarizes the contribu tions presented at the First International Symposium on Hodgkin's Disease that took place in Cologne (FRG) on October 2-3, 1988. There is little doubt that the Hodgkin and Reed-Sternberg (H and RS) cells and their variants represent the malignant population in Hodgkin's lymphoma; however, there is still a fierce debate as to the possible cell of origin of Hand RS cells. Many of the problems confounding earlier research into this question were related to the difficulty or virtual impossibility, of obtaining purified populations of Hand RS cells. Most of the recent progress stems from the establishment of permanent cell lines of Hand RS cells in culture.
Function and Regulation of Cellular Systems
Current biological research demands the extensive use of sophisticated mathematical methods and computer-aided analysis of experiments and data. This highly interdisciplinary volume focuses on structural, dynamical and functional aspects of cellular systems and presents corresponding experiments and mathematical models. The book may serve as an introduction for biologists, mathematicians and physicists to key questions in cellular systems which can be studied with mathematical models. Recent model approaches are presented with applications in cellular metabolism, intra- and intercellular signaling, cellular mechanics, network dynamics and pattern formation. In addition, applied issues such as tumor cell growth, dynamics of the immune system and biotechnology are included.
The Philosophical Diseases of Medicine and their Cure
At all times physicians were bound to pursue not only medical tasks, but to reflect also on the many anthropological and metaphysical aspects of their discipline, such as on the nature of life and death, of health and sickness, and above all on the vital ethical dimensions of their practice. For centuries, almost for two millennia, how ever, those who practiced medicine lived in a relatively clearly defined ethical and implicitly philosophical or religious 'world-order' within which they could safely turn to medical practice, knowing right from wrong, or at least being told what to do and what not to do. Today, however, the situation has radically changed, mainly due to three quite different...
Semantic Applications
This book describes methodologies for developing semantic applications. Semantic applications are software applications which explicitly or implicitly use the semantics, i.e. the meaning of a domain terminology, in order to improve usability, correctness, and completeness. An example is semantic search, where synonyms and related terms are used for enriching the results of a simple text-based search. Ontologies, thesauri or controlled vocabularies are the centerpiece of semantic applications. The book includes technological and architectural best practices for corporate use. The authors are experts from industry and academia with experience in developing semantic applications.
Business Information Systems Workshops
This book constitutes revised papers from the six workshops held at the 19th International Conference on Business Information Systems, BIS 2016, held in Leipzig, Germany, in July 2016. The workshops included in this volume are: * The 8th Workshop on Applications of Knowledge-Based Technologies in Business - AKTB2016 accepted 7 papers from 14 submissions and features 1 invited talk. * The 7th Workshop on Business and IT Alignment - BITA 2016 selected 6 papers from 12 submissions. * The Workshop on Big Data and Business Analytics Ecosystems - DeBASE 2016 has 4 papers in this volume. * The First International Workshop on Intelligent Data Analysis in Integrated Social CRM - iCRM 2016 features 5 ...
Stem Cell Applications in Diseases
Stem cells are the foundation cells for every organ, tissue and cell in the body. They are like a blank microchip that can ultimately be programmed to perform any number of specialised tasks. Stem cells are undifferentiated, "blank" cells that do not yet have a specific function. Under proper conditions, stem cells begin to develop into specialised tissues and organs. Additionally, stem cells are self-sustaining and can replicate themselves for long periods of time. These unique characteristics make stem cells very promising for supplying cells to treat debilitating diseases like Alzheimer's disease, cancer, Parkinson's disease, type-1 diabetes, spinal cord injury, stroke, burns, heart disease, osteoarthritis and rheumatoid arthritis. This new book presents the latest research in the field from around the world.
Miniatures in the Sicilian Najdorf
INSTRUCTIVE NAJDORF MINIATURES "An opening book based only on miniatures? Perhaps it sounds odd at first, but it works well in the sharp Najdorf, and even in the more positional Queen's Indian Defense. As usual Carsten's theoretical coverage is thorough, and the books are not repertoire based, but gives a full examination of these topical openings. Is it limiting only to show miniatures? Maybe, but one somehow get the purified version of a successful strategy, when the games are not complex battles, but a slam-dunk! - Grandmaster Peter Heine Nielsen, Coach & Second to World Champion Magnus Carlsen The purpose of the book is to entertain and educate you. The entertainment consists of 100 main...
AHA Scientific Sessions 2016: Program Information
The American Heart Association’s Scientific Sessions 2016 is bringing big science, big technology, and big networking opportunities to New Orleans, Louisiana this November. This event features five days of the best in science and cardiovascular clinical practice covering all aspects of basic, clinical, population and translational content.
Point Particles to Capture Polarized Embryonic Cells & Cold Pools in the Atmosphere
Part 1: How are the incredible diversity and robustness compatible with animal morphologies? Based on apical-basal and planar cell polarities’ ubiquity, I suggest a 3D mathematical model: Point particles represent cells having zero, one, or two unit-arrows representing polarities. I test the model abilities on preimplantation development, sea urchin gastrulation, mammalian neurulation, organoid folding, and tubulogenesis. I find that a minimal, versatile toolbox, including cellular polarities, captures the emergence of diverse and robust animal morphologies. Part 2: How are deep convective events spatially organized in the tropical atmosphere? Here, I test the importance of atmospheric cold pools for organizing convection. I suggest a 2D mathematical model: Points expand into circles representing cold pools. When circles meet, a convective event occurs, and a new circle forms. I find this model captures convective scale increase and initial stages of convective self-aggregation. The latter is crucial due to its link to tropical cyclogenesis.
