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This revised and extended second edition focuses on current and emerging topics in drug development, their molecular mechanisms of action as well as regulatory issues. In addition, in-depth insights into clinical drug research and trial methodology are presented on the basis of concrete case studies. This updated book makes a valuable contribution to the field of Clinical Pharmacology and serves as a must-have guide for professors, researchers and advanced students from academia and pharmaceutical industry.
A vast number of diagnostic and therapeutic decisions are based on measuring blood concentrations of molecules, yet most biochemical and pharmacological events actually take place in the tissues. Microdialysis is a key semi-invasive sampling technique to measure in vivo drug penetration to the target site in humans, the method being feasible in virtually every organ. Authored by international experts in this cutting edge field, this book will provide a comprehensive overview of microdialysis and its application for measuring drug distribution in drug development.
Picasso met Francoise Gilot, the young French student who was to become his muse and favorite model, while waiting out the war years in Paris. She appeared again and again in his works of the 1940s and 50s, often with her face stylized to recall the sun or a plant. It was also during this period--known as his Periode Francoise--that Picasso employed a cheerful palette not seen before in his work. His concurrent interest in the motifs of Mediterranean antiquity and mythology, from dancing centaurs to music-making fauns, is attributed to a stay in the Cap d'Antibes on the Cote d'Azur in 1946. In this volume, internationally recognized French and German Picasso scholars consider the different facets of the artist's work during this period. Rich illustrations illuminate the connections between the motifs of his paintings and sculptural and graphic work. Also included are reproductions of Francoise Gilot's own work, thus allowing entry into the artistic dialogue that occurred between Picasso and his young partner, who separated from him in 1953.
Artwork by Pablo Picasso. Edited by Markus Muller.
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Essay by Markus Muller.