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Selenium
This book examines the molecular biology of selenium and how this element makes its way into protein. The role of this element in preventing certain forms of cancer, heart disease and other cardiovascular and muscle disorders is explored in the text. The Second Edition outlines discoveries since the book was first introduced in 2001. Chapter updates have been written by investigators who have made important contributions to the field.
Selenium
Many health benefits have been attributed to selenium that include preventing various forms of cancer (e.g., colon cancer, prostate cancer, lung cancer and liver cancer), heart disease and other cardiovascular and muscle disorders, inhibiting viral expression, delaying the progression of acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus (HIV)-positive patients, slowing the aging process, and having roles in mammalian development, including male reproduction and immune function. The purpose of the book is the same as the first two volumes which is to bring an up to date status of current research in the rapidly developing selenium field centered around the health benefits attributed to this element and how this element makes its way into protein.
Selenium
As discussed in this book, a large body of evidence indicates that selenium is a cancer chemopreventive agent. Further evidence points to a role of this element in reducing viral expression, in preventing heart disease, and other cardiovascular and muscle disorders, and in delaying the progression of AIDS in HIV infected patients. Selenium may also have a role in mammalian development, in male fertility, in immune function and in slowing the aging process. The mechanism by which selenium exerts its beneficial effects on health may be through selenium-containing proteins. Selenium is incorporated into protein as the amino acid selenocysteine. Selenocysteine utilizes a specific tRNA, a specific elongation factor, a specific set of signals, and the codeword, UGA, for its cotranslational insertion into protein. It is indeed the 21st naturally occurring amino acid to be incorporated into protein and marks the first and only expansion of the genetic code since the code was deciphered in the mid 1960s.
Protein Sensors of Reactive Oxygen Species, Part A: Selenoproteins and Thioredoxin
This volume of Methods in Enzymology is concerned with the rapidly developing field of selenoprotein synthesis and its related molecular genetics. Progressive information on the topics of proteins as redox sensors, selenoproteins, and the thioredoxin system is studied using methods such as bioinformatics, DNA chip technology, cell biology, molecular genetics, and enzymology. The information on novel selenoproteins identified from genomic sequence data, as well as current knowledge on glutathione peroxidases, selenoprotein P, iodothyronine deiodinases, and thioredoxin reductases, is presented in a method-based approach.
Combinatorial Pattern Matching
This book constitutes the refereed proceedings of the 15th Annual Symposium on Combinatorial Pattern Matching, CPM 2004, held in Istanbul, Turkey in July 2004. The 36 revised full papers presented were carefully reviewed and selected from 79 submissions. The papers are devoted to current theoretical and computational aspects of searching and matching of strings and more complicate patterns, such as trees, regular expressions, graphs, point sets, and arrays. Among the application fields addressed are computational biology, bioinformatics, genomics, proteinomics, the web, data compression, coding, multimedia, information retrieval, data analysis, pattern recognition, and computer vision.
Thyroid Hormone MetabolismMolecular Biology and Alternate Pathways
This book gathers some of the most talented and well-informed experts in the field, who not only summarize the recent breakthroughs and new findings, but also shed light on future research. Special emphasis is placed on the exciting new understanding of the molecular structure of one of the major enzymes (type 1 iodothyronine deiodinase) involved in the activation of the thyroid hormone. This breakthrough culminates the major effort in this field around the world. As a result, we can study the regulation of thyroid hormone activation mechanism at the molecular level. Two other important deiodinase enzymes (types II and III) are also reviewed. Alternate pathways of thyroid hormone metabolism represent another major advance. These pathways are associated with a variety of physiological and disease states, including fasting, glucocorticoid excess, fetal development, and inflammatory and non-thyroidal illnesses. The understanding of these pathways assists us to better understand the physiological and biological basis of the disease process and thus to improve clinical management of patients with thyroidal and non-thyroidal illnesses.
Oxidative Stress in Vertebrates and Invertebrates
This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.
Advances in Intelligent Data Analysis
This book constitutes the refereed proceedings of the 4th International Conference on Intelligent Data Analysis, IDA 2001, held in Cascais, Portugal, in September 2001.The 37 revised full papers presented were carefully reviewed and selected from a total of almost 150 submissions. All current aspects of this interdisciplinary field are addressed; the areas covered include statistics, artificial intelligence, neural networks, machine learning, data mining, and interactive dynamic data visualization.
