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Aging, neurogenesis and neuroinflammation in hearing loss and protection
Worldwide, 278 million people are estimated to have moderate to profound hearing loss. Age-related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. Hearing loss occurs when the sensory cells and neurons of the cochlea degenerate and die. The vestibular system, which holds the sense of balance, shares a common embryonic origin with the cochlea and together conform the inner ear. Balance problems are a trait of ageing to the point that balance ability is considered a sensor of physical decline and vestibular degeneration is the most common cause of falls in the elderly...
Sebastian’s Way
IN A DARK AGE OF UNENDING WAR AND VIOLENCE, ONE YOUNG WARRIOR OPPOSES A MIGHTY KING TO FORGE A NEW PATH TO PEACE... During the savage Frankish-Saxon wars, the moving force of his age, Karl der Grosse, King Charlemagne, fights and rules like the pagan enemies he seeks to conquer. But in the long shadow of war and genocide, a spark of enlightenment grows, and the king turns to learned men to help him lead his empire to prosperity. One of these men is the unlikely young warrior Sebastian. Raised in an isolated fortress on the wild Saxon border, Sebastian balances his time in the training yard with hours teaching himself to read, seeking answers to the great mysteries of life during an age when ...
Computational Intelligence Methods for Bioinformatics and Biostatistics
This book constitutes the thoroughly refereed post-conference proceedings of the 12th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2015, held in Naples, Italy, in September, 2015. The 21 revised full papers presented were carefully reviewed and selected from 24 submissions. They present problems concerning computational techniques in bioinformatics, systems biology and medical informatics discussing cutting edge methodologies and accelerate life science discoveries, as well as novel challenges with an high impact on molecular biology and translational medicine.
Learning with Kernels
A comprehensive introduction to Support Vector Machines and related kernel methods. In the 1990s, a new type of learning algorithm was developed, based on results from statistical learning theory: the Support Vector Machine (SVM). This gave rise to a new class of theoretically elegant learning machines that use a central concept of SVMs—-kernels—for a number of learning tasks. Kernel machines provide a modular framework that can be adapted to different tasks and domains by the choice of the kernel function and the base algorithm. They are replacing neural networks in a variety of fields, including engineering, information retrieval, and bioinformatics. Learning with Kernels provides an introduction to SVMs and related kernel methods. Although the book begins with the basics, it also includes the latest research. It provides all of the concepts necessary to enable a reader equipped with some basic mathematical knowledge to enter the world of machine learning using theoretically well-founded yet easy-to-use kernel algorithms and to understand and apply the powerful algorithms that have been developed over the last few years.
Inclusion and Diversity in Education: Inclusive pedagogy in curricula and classrooms
This 4-volume set brings together seminal articles and key writings on the theme of inclusion and diversity in education. The collection takes disability and special educational need as a starting point from which to develop a broader focus on a range of themes relating to learners who may be marginalised from educational opportunities. This includes for example members of minority ethnic communities, students excluded from schools or who are 'looked after' in public care, and other dimensions of exclusion arising from social class, gender or sexuality. The starting point for understanding inclusive education lies in social justice perspectives, and this forms the basis for the first volume....
Backfire
CHICAGO-THE GEM OF THE PRAIRIE-EARLY AUTUMN, 1871 The city was alive. Raw materials and finished goods moved as fast as the new railroads and lake schooners could carry them. Wisconsin white pine lumber was big business in a city composed of thousands of wooden structures connected by wooden sidewalks and wooden-block streets. Competition was fierce, ruthless, and deadly. An Eau Claire lumberman is killed in his hotel room and a competitor, Arlyn Rygg, from Green Bay, must work with the police to find the real killer in order to exonerate himself. His inquiries draw him into a maelstrom of intrigue and deception. Ultimately he races through the Great Fire and learns more than he ever wanted to know. Praise for Natural Drift, a contemporary Western action mystery pinning a Montana County Sheriff against a rogue U.S. Marshall. I am writing to let you know how much I enjoyed your novel, Natural Drift. I found it to be a very good read with a realistic plot and well developed characters. I honestly could not put it down once I started it. Sheriff Thomas Rieger, Carbon County, Montana
