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Update on Hepatitis C
In the past few years, remarkable progress has been made in our understanding of HCV biology, pathogenesis of infection, and structure-function relationships. This has led to quantum advances in clinical efficacy and tolerability. Yet, in spite of this amazing progress, there remain obstacles to widespread successful treatment. These issues include biological failures even with direct-acting agents, lack of options for individual with organ failures, drug-drug interactions, access to medications either due to lack of availability or affordability, and psychiatric and social issues. These problems are likely to remain in the future. Therefore, this book has been created by distinguished faculties from around the world to address the progress in our understanding of HCV infection and to review new treatment options, limitations, and accessibility of new therapeutic options.
Kidney Inflammation, Injury and Regeneration
Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different ...
Management of Occult GI Bleeding
This book provides a concise, state-of-the-art overview of occult GI bleeding. The text reviews the epidemiology, screening and detection methods for localization, and prominent treatment strategies for occult GI bleeding. It also features a dedicated section on special patient populations including children, premenopausal women, older adults, and patients with other predisposing, and complicating medical conditions. This volume is supplemented with numerous color illustrations, photographs, and table, and is one of the few dedicated resources on occult GI bleeding. Written by experts in the field, Management of Occult GI Bleeding: A Clinical Guide is a valuable resource for clinicians, practitioners, and students who are involved in the treatment of patients with occult GI bleeding.
Drug Discovery
The book "Drug Discovery - Concepts to Market" is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the latest drug discovery trends that have been revolutionized with up-to-date technological developments. This book comprises single chapters authored by various researchers and edited by an expert active in the drug development research area. All chapters are independently complete but united under a common research study topic. This publication aims to provide a thorough overview of the latest research efforts in this field from international authors and open new possible research paths for further novel developments.
Pharmacogenomics in Clinical Practice
This book provides a practically applicable guide to the applications of pharmogenomics across medicine. Background information is provided on the mechanisms associated with membrane transporters, drug-metabolizing enzymes and their importance in pharmagenomics. Detailed guidance is subsequently presented on how to apply these techniques in disciplines including cardiology, gastroenterology, oncology, transplantation surgery, infectious diseases, anesthesia and analgesia, neurology, psychiatry, primary care, and public health. Clear easy-to-follow instructions are given on how to use big data technologies and public health databases in day-to-day clinical practice. Pharmacogenomics in Clinical Practice concisely covers how pharmacogenomic technologies and techniques can be applied in daily medical practice. It is therefore an ideal up-to-date resource for any medical practitioner, trainee or researcher across all medical disciplines who want to better understand how to use these techniques.
Drug Discovery and Development
It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.
Endocrinologia em casos clínicos
O livro Endocrinologia em Casos Clínicos foi idealizado e escrito por acadêmicos do curso de Medicina da Universidade Federal do Ceará – campus Sobral, tendo o apoio de profissionais capacitados de Sobral e Fortaleza, no estado do Ceará, para a sua correção. Esta obra tem como principal finalidade apresentar, de forma simples e objetiva, casos clínicos sobre as patologias mais frequentes em endocrinologia e oferecer informações diagnósticas e terapêuticas atualizadas que contribuirão para o aprendizado de alunos da graduação, residentes e médicos das mais diversas áreas da medicina que queiram se atualizar e relembrar temas importantes para a prática cotidiana referentes à endocrinologia. Os capítulos são organizados para incitar a capacidade de raciocínio diagnóstico do leitor e expandir as opções de diagnósticos diferenciais incluídos ou não no âmbito endocrinológico, além de contribuir para a fixação da maneira correta de condução dos pacientes. Ademais, trouxemos fluxogramas em todos os capítulos, os quais têm como finalidade a consulta rápida, possibilitando oferecer aos pacientes uma assistência mais ágil.
Drug Discovery
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Social, Health, and Economic Impacts of the COVID-19 Pandemic and the Epidemiological Control Measures
The COVID-19 pandemic posed a major threat to the well-being of older Europeans. Its economic and social effects, however, varied across countries. This multidisciplinary book presents the first results of analyses that combined the renowned longitudinal database of SHARE with new data from two telephone surveys that were uniquely conducted during the pandemic. The analyses address important policy-related issues, such as: Did social distancing destabilize family and social support networks? Did the pandemic increase health, social and economic inequality? Who had to forego essential health care because of the pandemic? Did lockdown affect one's physical and mental health? Did the shift towards remote work affect workload and well-being? Were different housing conditions related to the spread of the virus?
