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Several fundamentally important questions form the basis for this book. What are the relationships between tumour formation and tumour pH? What are the effects of tumour pH and hypoxia on carcinogenesis or tumorigenesis? What are the therapeutic consequences of tumour pH? It is hypothesised that low extracellular pH is not only an important consequence of tumour growth but may also promote further tumorigenic transformation. Furthermore, in vitro studies suggest that low pH strongly affects the efficacy of chemo- and radiotherapy. Better understanding of the influence of pH on tumour growth, coupled with manipulation of the pH of the tumour microenvironment, may lead to the development of more effective therapies.
The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.
This book sheds new light on language and literature teaching, and offers examples of teaching language in virtual environments. Providing an overview of virtual environments for teaching, it also includes chapters devoted to methodology design for second language teaching in these environments. Further it describes tools for second/ foreign language teaching and proposals for specific second language teaching in virtual environments. Lastly, it presents experiments on literature teaching in virtual environments and discusses the future of technology in education. With interdisciplinary appeal, the book is a particularly valuable resource for scholars with an interest in technology, language teaching and literature teaching.
Electrospinning is a versatile and effective technique widely used to manufacture nanofibrous structures from a diversity of materials (synthetic, natural or inorganic). The electrospun nanofibrous meshes’ composition, morphology, porosity, and surface functionality support the development of advanced solutions for many biomedical applications. The Special Issue on “Electrospun Nanofibers for Biomedical Applications” assembles a set of original and highly-innovative contributions showcasing advanced devices and therapies based on or involving electrospun meshes. It comprises 13 original research papers covering topics that span from biomaterial scaffolds’ structure and functionalization, nanocomposites, antibacterial nanofibrous systems, wound dressings, monitoring devices, electrical stimulation, bone tissue engineering to first-in-human clinical trials. This publication also includes four review papers focused on drug delivery and tissue engineering applications.
This book provides an overview of the design and physico-chemical properties of nanoparticles developed for biomedical applications such as targeting and detection of pathologies, nanovectorization of drugs, radiosensitization, metal detection, and nanocomposite implants. The considerations necessary when developing a new nanomedicine are also developed, including toxicological investigation, biodistribution, and efficacy. This book provides an accurate and current representation of the field by addressing the promises and hurdles of nanomedicine via 20 different pertinent studies. Covering a wide range of areas, this book is an excellent partner for physico-chemists, doctors, pharmacologists, and biochemists working on nanosciences dedicated to medicine, both in industry and in academia.
La bienal de resonancia magnética nuclear (RMN) es un congreso consolidado dentro del grupo especializado de RMN español (GERMN) desde su primera edición celebrada en Calella en 2002, hasta esta última celebrada en Almería en 2022. Este congreso es de hecho la principal actividad de difusión y promoción de la investigación realizada en España que utiliza la RMN como plataforma espectroscópica esencial para alcanzar sus objetivos. La bienal de este año ha tenido entre uno de sus objetivos el promover el establecimiento de colaboraciones y redes entre grupos de RMN españoles e internacionales, centrándose en los principales avances y desarrollos recientes sobre biomacromoléculas,...
The huge increase in potential applications of polymer nanocomposites have made it necessary for researchers to address the fire safety issues of these materials.Flame Retardant Nanocomposites: Emergent Nanoparticles and their Applications covers the broad area of flame- retardant polymer nanocomposites, their preparation, fire retardant mechanisms and the various factors that affect them. The influence of various nanoparticles on their flammability is discussed in detail, as well as their structure, free radical trapping ability, char formation, and eventual barrier properties.The book will be a valuable reference resource for students, researchers and engineers covering this important field of research. The chapters discuss the effect of different nanoparticles, their dispersion, and effect of different polymer structures on fire retardant properties, as well as possible applications. - Provides a detailed overview of fire retardant polymer nanocomposite systems, including different nanofillers - Describes fire mechanisms behind nanocomposite structure and morphology - Covers the latest developments and the most recent applications in industry, defense, and space