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Biomarkers in Cancer Detection and Monitoring of Therapeutics
Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics: Volume Two: Diagnostic and Therapeutic Applications discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancers. It focuses on novel diagnostic techniques based on molecular biomarkers and their impact on treatment, covering different cancer types such as tumors in the nervous system, head and neck, oral and GI tractor, lung, breast, gastric system, leukemia and urogenital tract cancers. For each type, the book discusses the best diagnostic techniques and therapeutic approaches, thus helping readers easily identify...
Delineating Health and Health System: Mechanistic Insights into Covid 19 Complications
This book discusses the organ-specific systemic manifestations of COVID-19. The initial chapters of the book review the origin and evolution of the coronaviruses, followed by pathogenesis and immune response during COVID-19 infection. The book also provides insight into the role of angiotensin-converting enzyme 2 in the onset of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. It summarizes the neurological aspects of SARS-CoV2, including transmission pathways, mechanisms of invasion into the nervous system, and mechanisms of neurological disease. It also delineates the association of severe disease with high blood plasma levels of inflammatory cytokines and inflammatory markers in SARS-CoV-2 infection. Lastly, it discusses the perturbation of gut microbiota by SARS-CoV-2 and uncovers the potential risk of virus infection on reproductive health.
The Story of the Pasteur Institute and Its Contributions to Global Health
Despite the fame surrounding the name of Louis Pasteur, few people know what exactly occurs at the institute he founded in 1887. Scientific breakthroughs made by pioneers of microbiology, the emergence of molecular biology and genomics, and the identification of VIH–1 in 1983 have kept the Pasteur Institute at the forefront of the fight against infectious diseases. This prestigious private foundation has upheld the vision of its founder, creating a Pasteurian community worldwide, with 33 Pasteur Institutes on five continents, and supported by both famous and unknown donors throughout the world. This book presents the fascinating story of an institution which had enormous influence on both British and American science and medicine. It offers detailed and personal insights into the Pasteur Institute, where lively personalities and outsized passions give birth to excitement and the triumph of world-class research.
Human Geoscience
This book is a product of the joint efforts of interdisciplinary academic fields under the integrative framework of human geoscience. Human geoscience is a new genre of geoscience concerned with the natural phenomena that occur on the surface of the Earth and their relations with human activities. It therefore has connections with many fields of geoscience, namely, physical geography, geomorphology, geology, soil science, sedimentology, seismology, volcanology, meteorology, climatology, oceanography, and hydrology. It also has strong links to the humanities, social sciences, agricultural sciences, and engineering related to disaster prevention or mitigation. All these disciplines are importa...
Physics of Biological Oscillators
This book, based on a selection of invited presentations from a topical workshop, focusses on time-variable oscillations and their interactions. The problem is challenging, because the origin of the time variability is usually unknown. In mathematical terms, the oscillations are non-autonomous, reflecting the physics of open systems where the function of each oscillator is affected by its environment. Time-frequency analysis being essential, recent advances in this area, including wavelet phase coherence analysis and nonlinear mode decomposition, are discussed. Some applications to biology and physiology are described. Although the most important manifestation of time-variable oscillations is arguably in biology, they also crop up in, e.g. astrophysics, or for electrons on superfluid helium. The book brings together the research of the best international experts in seemingly very different disciplinary areas.
Role of Microbes in Sustainable Development
This book examines the role of human microbiome in human health and diseases. The initial chapters present tools for genetic manipulation of gut microbiota and the therapeutic applications of engineered microbiota. They discuss the interaction between human microbiota and host in defining the prominent role of microbes in the development and progression of major human diseases. The book also summarizes the current applications and trends for the development, production and analytical characterization of recombinant therapeutic proteins in microbial systems. It also reviews the role of microbes in the production of vaccines and antibiotics. Further, the book presents bacterial products, inclu...
The Art of Computer Programming, Volume 4A
The Art of Computer Programming, Volume 4A: Combinatorial Algorithms, Part 1 Knuth’s multivolume analysis of algorithms is widely recognized as the definitive description of classical computer science. The first three volumes of this work have long comprised a unique and invaluable resource in programming theory and practice. Scientists have marveled at the beauty and elegance of Knuth’s analysis, while practicing programmers have successfully applied his “cookbook” solutions to their day-to-day problems. The level of these first three volumes has remained so high, and they have displayed so wide and deep a familiarity with the art of computer programming, that a sufficient “review...
Biomedical Translational Research
This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. It emphasizes the importance of understanding biological and pathophysiological mechanisms underlying the disease to discover and develop new biological agents. The book uniquely explores the genomic computational integrative approach for drug repositioning. Further, it discusses the health benefits of nutraceuticals and their application in human diseases. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning. Finally, it summarizes the major challenges in drug development and the strategies for the rational design of the next generation more effective but less toxic therapeutic agents.
