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Advances in Clinical Chemistry
Volume 56 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology. - Written by authors representing the diverse field of clinical chemistry and diagnostics, reviews in Advances in Clinical Chemistry cover a range of cutting-eduge research ranging from basic biochemical exploration to microarray technology
Complement Therapeutics
This book highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis. In addition, complement is often involved in adverse immune reactions to biomaterials, cell and organ transplants or drug delivery systems. Although the complement cascade with its close to 50 extrac...
Advanced Information Systems Engineering
As humanity approaches the 3rd millennium, the sustainability of our present way of life becomes more and more questionable. New paradigms for the long-term coevolution of nature and civilization are urgently needed in order to avoid intolerable and irreversible modifications of our planetary environment. Earth System Analysis is a new scientific enterprise that tries to perceive the earth as a whole, a unique system which is to be analyzed with methods ranging from nonlinear dynamics to macroeconomic modelling. This book, resulting from an international symposium organized by the Potsdam Institute, has 2 aims: first, to integrate contributions from leading researchers and scholars from around the world to provide a multifaceted perspective of what Earth System Analysis is all about, and second, to outline the scope of the scientific challenge and elaborate the general formalism for a well-defined transdisciplinary discourse on this most fascinating issue.
The Collectin Protein Family and Its Multiple Biological Activities
The topic of this book, Collectins, is a family of proteins whose major function is in innate immunity, where Collectins act as pattern recognition receptors (PRRs). In general they recognize targets such as microbial surfaces and apoptotic cells, and once bound to a target, Collectins promote the clearance of microorganisms and damaged host tissue. New cell-surface proteins and glycoproteins, which act as Collectin receptors, are currently being identified. Some Collectins, particularly MBL, activate the complement system, which enhances the ability of antibodies to fight pathogens, via three MBL-associated proteases, the MASPs. Additionally, recent research has begun to show wider-ranging ...
Esprit ’89
The 6th ESPRIT Conference is being held in Brussels from the 27th November to the 1 st December 1989. Well over 1500 participants from all over Europe are expected to attend the various events during the week. The Conference will offer the opportunity to be updated on the results of ongoing Esprit projects and to develop Europe-wide contacts with colleagues, both within a specific branch of Information Technology and across different branches. The first three days of the week are devoted to presentations of Esprit I projects, structured into plenary and parallel sessions; this year there is special emphasis on panels and workshops where participants can exchange ideas and hold in-depth discu...
Molecular Aspects of Innate and Adaptive Immunity
Focuses on innate and adaptive immunity with emphasis on the protein chemistry of the system. This volume provides an insight and understanding at the molecular level, of the interactions between innate and adaptive arms of the immune system. It is suitable for academics, students and established scientists and professionals.
Immunobiology of Carbohydrates
This book is unique in providing pertinent information on the various established roles carbohydrate play in the immune system and how the innate and adaptive immune systems respond to this type of microbial antigens. The editors selected only topics that have established basic and clinical relevance to this field. The topics from basic research are organised like a textbook, in order to guide the readers through complex sets of events that lead to clearance of or to immune responses toward carbohydrate antigens. The book is clear, concise and contains fully annotated summaries of the key basic and practical information on carbohydrate immunology from current literature. These topics are wri...
Proteases in Physiology and Pathology
Using a multidisciplinary approach, this book describes the biochemical mechanisms associated with dysregulation of proteases and the resulting pathophysiological consequences. It highlights the role and regulation of different types of proteases as well as their synthetic and endogenous inhibitors. The role of proteases was initially thought to be limited to general metabolic digestion. However, we now know that the role of protein breakdown is much more complex, and proteases have multiple functions: they are coupled to turnover and can affect protein composition, function and synthesis. In addition to eliminating abnormal proteins, breakdown has many modulatory functions, including activa...
