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Synthesis and application of ?-configured [18/19F]FDGs
  • Language: en
  • Pages: 125

Synthesis and application of ?-configured [18/19F]FDGs

Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. The by far most widely employed radiotracer in PET is called 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), which is often referred to as the golden standard in PET. From a molecular perspective, [18F]FDG is an analogue of glucose where a hydroxyl group has been replaced with a radioactive fluorine atom (18F). It is well known that covalent attachme...

Multimodal Porphyrin-Based Conjugates
  • Language: en
  • Pages: 105

Multimodal Porphyrin-Based Conjugates

Organic compounds that interact both with certain biological targets and display specific photophysical properties can be utilized as molecular tools to visualize and possibly effect disease related processes taking place in living organisms. In this regard, porphyrins are a class of naturally occurring molecules that possess intriguingly interesting photophysical properties where they can act as luminescent probes by emitting detectable light, as well as photosensitizers in the light mediated therapy called photodynamic therapy. In this thesis, the porphyrin structure has been synthetically combined with other molecule classes to achieve compounds with desirable multimodal characteristics. ...

An insight into the metabolism of New Psychoactive Substances
  • Language: en
  • Pages: 108

An insight into the metabolism of New Psychoactive Substances

New Psychoactive Substances (NPS) is an umbrella term covering hundreds of substances across different drug groups. Many of these substances were originally developed for therapeutic use but have later appeared on the recreational drug market. The use of NPS has been associated with many outbreaks leading to hospitalizations and has been implicated in numerous fatalities worldwide. To be able to analytically detect drugs in a forensic setting is vital in the fight against the abuse of NPS. One of the most notable challenges in detection of NPS is the identification of major urinary metabolites for use as biomarkers. Furthermore, given the lack of reference standards in most metabolism studie...

Organofluorine Chemistry
  • Language: en
  • Pages: 464

Organofluorine Chemistry

By presenting novel methods for the efficient preparation of fluorinated compounds and their application in pharmaceutical and agrochemical chemistry as well as medicine, this is a valuable source of information for all researchers in academia and industry!

The Behavioural Biology of Chickens
  • Language: en
  • Pages: 202

The Behavioural Biology of Chickens

  • Type: Book
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  • Published: 2015-05-28
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  • Publisher: CABI

Chickens are by far the world’s most widely farmed animal, kept for both meat and egg production. They are at the centre of many debates regarding housing and production systems, causing significant interest in what lies behind chicken behaviour. This accessible book covers sensory biology, behavioural development, preferences and aversions, social behaviour, learning and cognition, behavioural issues in different systems and solutions for behavioural problems. Authored by an authority on chicken ethology, it brings together the fields of animal behaviour, neuroscience, psychology and epidemiology to provide a comprehensive understanding of chicken behaviour and help improve the lives of farmed chickens around the world.

Emerging Fluorinated Motifs, 2 Volume Set
  • Language: en
  • Pages: 870

Emerging Fluorinated Motifs, 2 Volume Set

A must-have resource for all the researchers working in the organofluorine and related fields This timely two-volume set uniquely focuses on emerging fluorinated motifs beyond R-CF3 and R-F, like R-CF2H, R-OCF3, R-SCF3 and R-SF5. It also offers descriptions of the properties, synthesis, and applications of these emerging fluorinated motifs in order to help readers design new chemical entities, while providing new interest for researchers in organofluorine chemistry and new tools for those in other areas. Emerging Fluorinated Motifs: Synthesis, Properties and Applications begins with a description of carbon-linked fluorine-containing groups that include monofluoromethyl and difluoromethyl gro...

Biohybrid Systems
  • Language: en
  • Pages: 231

Biohybrid Systems

The discipline of neurodesign is a highly interdisciplinary one, while at the same time in the process of maturing towards real-life applications. The breakthrough about to be achieved is to close the loop in communication between neural systems and electronic and mechatronic systems and actually let the nervous system adapt to the feedback from the man-made systems. To master this loop, scientists need a sound understanding of neurology, from the cellular to the systems scale, of man-made systems and how to connect the two. These scientists comprise medical scientists, neurologists and physiologists, engineers, as well as biophysicists. And they need the topics in a coherently written work with chapters building upon another.

Bioorganic and Medicinal Chemistry of Fluorine
  • Language: en
  • Pages: 385

Bioorganic and Medicinal Chemistry of Fluorine

Provides a thorough overview of the role of fluorine in pharmaceutical science and development Includes chapters on fluorinated analogues of natural products, fluorinated amino acids and peptides, and derivatives of sugars Classifies marketed and in-development fluorinated pharmaceuticals according to their therapeutic classes

Handbook of Radiopharmaceuticals
  • Language: de
  • Pages: 768

Handbook of Radiopharmaceuticals

The thoroughly updated new edition of the authoritative reference in Radiopharmaceutical Sciences The second edition of Handbook of Radiopharmaceuticals is a comprehensive review of the field, presenting up-to-date coverage of central topics such as radionuclide production, synthetic methodology, radiopharmaceutical development and regulations, and a wide range of practical applications. A valuable reference work for those new to the Radiopharmaceutical Sciences and experienced professionals alike, this volume explores the latest concepts and issues involving both targeted diagnostic and therapeutic radiopharmaceuticals. Contributions from a team of experts from across sub-disciplines provid...

The Knights Templar in Somerset
  • Language: en
  • Pages: 128

The Knights Templar in Somerset

This fascinating new book explores what life was like during the Templars' stay in Somerset during the thirteenth and fourteenth centuries. It reveals the struggles over land ownership in the county, and introduces the reader to little known historical characters including William de Marisco, revealing his struggle with the Templars, and claim to the throne of England. The final chapter explores the controversy surrounding a carved wooden man's head discovered in a Somerset church. The author has found compelling evidence to suggest the church was not only built on Templar land, but had a connection with the Grand Master of the Order himself. Richly illustrated and compiled using original research, this book is sure to appeal to everyone interested in medieval history.