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Science of Microscopy
This fully corrected second impression of the classic 2006 text on microscopy runs to more than 1,000 pages and covers up-to-the-minute developments in the field. The two-volume work brings together a slew of experts who present comprehensive reviews of all the latest instruments and new versions of the older ones, as well as their associated operational techniques. The chapters draw attention to their principal areas of application. A huge range of subjects are benefiting from these new tools, including semiconductor physics, medicine, molecular biology, the nanoworld in general, magnetism, and ferroelectricity. This fascinating book will be an indispensable guide for a wide range of scientists in university laboratories as well as engineers and scientists in industrial R&D departments.
Springer Handbook of Microscopy
This book features reviews by leading experts on the methods and applications of modern forms of microscopy. The recent awards of Nobel Prizes awarded for super-resolution optical microscopy and cryo-electron microscopy have demonstrated the rich scientific opportunities for research in novel microscopies. Earlier Nobel Prizes for electron microscopy (the instrument itself and applications to biology), scanning probe microscopy and holography are a reminder of the central role of microscopy in modern science, from the study of nanostructures in materials science, physics and chemistry to structural biology. Separate chapters are devoted to confocal, fluorescent and related novel optical micr...
Membrane Biophysics
This book highlights recent advances in and diverse techniques for exploring the plasma membrane’s structure and function. It starts with two chapters reviewing the history of membrane research and listing recent advances regarding membrane structure, such as the semi-mosaic model for red blood cell membranes and the protein layer-lipid-protein island model for nucleated tissue cell membranes. It subsequently focuses on the localization and interactions of membrane components, dynamic processes of membrane transport and transmembrane signal transduction. Classic and cutting-edge techniques (e.g. high-resolution atomic force microscopy and super-resolution fluorescence microscopy) used in biophysics and chemistry are presented in a very comprehensive manner, making them useful and accessible to both researchers in the field and novices studying cell membranes. This book provides readers a deeper understanding of the plasma membrane’s organization at the single molecule level and opens a new way to reveal the relationship between the membrane’s structure and functions, making it essential reading for researchers in various fields.
Advanced Imaging in Biology and Medicine
A picture says more than a thousand words. This is something that we all know to be true. Imaging has been important since the early days of medicine and bi- ogy, as seen in the anatomical studies of Leonardo Da Vinci or Andreas Vesalius. More than 100 years ago, the ?rst noninvasive imaging technologies, such as K- rad Roentgen’s X-ray technology,were applied to the medical ?eld—and while still crude—revolutionized medical diagnosis. Today, every patient will be exposed to some kind of advanced imaging technology such as medical resonance imaging, computed tomography or four-dimensional ultrasound during their lifetime. Many diseases, such as brain tumors, are initially diagnosed sole...
Oxidative Stress in Lung Diseases
This is the second volume of the comprehensive, two-volume work on oxidative stress in lung diseases. Adopting a multidisciplinary approach, it demonstrates the cellular and molecular mechanisms associated with ROS (reactive oxygen species)-induced initiation and progression of a variety of lung diseases, such as COPD, emphysema, asthma, cystic fibrosis, occupational pulmonary diseases and pulmonary hypertension and discusses points for therapeutic intervention. The book also covers translational research and the latest research on prevention and therapeutics. Each chapter includes in-depth insights into the mechanisms associated with lung diseases and into identifying targets for drug development. Bridging the gap between fundamental and translational research, and examining applications in the biomedical and pharmaceutical industry, it is a thought- provoking read for basic and applied scientists engaged in biomedical research.
The Curse of the Labrador Duck
In an obsessive 82,000-mile quest for dead birds, how much trouble can one scientist get into? Finally, the world's leading authority on the extinct Labrador Duck, Dr. Glen Chilton, shares the story of his frenzied obsession to reveal the histories behind the mysterious bird -- a saga wherein he sets out to examine the remains of every Labrador Duck, conduct genetic analysis on every Labrador Duck egg, and visit every site where the duck was shot...with many a (mis)adventure along the way. More elusive than the Passenger Pigeon, the Dodo, or the Great Auk and breeding in places so obscure that no certain records exist of its nests, the Labrador Duck succumbed to extinction almost before anyo...
STM and SFM in Biology
STM and SFM in Biology is a book fully dedicated to biological applications of the new technology of scanning probe microscopy (SX). The scanning tunneling microscope (STM) and its first off-spring, the scanning force microscope (SFM), resolve surface topography at the atomic scale. They also detect certain electronic and mechanical properties, and perform well in ultrahigh vacuum, ambient atmosphere, and aqueous solution environments. Thus, STM and SFM offer powerful tools for biological investigations of nucleic acids, proteins, membranes, and living cells. - Introduces the reader to SXM - Presents fundamentals of STM, SFM, and other SXMs - Covers biological applications of STM and SFM - Describes experimental techniques that can be reproduced in the laboratory - Contains extended bibliographies that guide the reader to detailed source publications
Applied Scanning Probe Methods XI
The volumes XI, XII and XIII examine the physical and technical foundation for recent progress in applied scanning probe techniques. These volumes constitute a timely comprehensive overview of SPM applications. Real industrial applications are included.
Molecular Mechanisms of Synaptogenesis
This book provides a new compilation of information that link changes in the basic structure of synapses and brain diseases. The book shows that specific secreted proteins, and short peptide mimicking the function of neural cell adhesion molecules can significantly enhance the formation of synapses in the brain. It describes recent advances in research that lay necessary scientific groundwork to develop pharmacological treatments.
Nano- and Microparticle-Induced Cell Death, Inflammation and Immune Responses
Nano- and microparticles including crystals, synthetic biomaterials, misfolded proteins or environmental particulates are involved in a wide range of biological processes and diseases. They may present as intrinsic or environmental toxins but may also be applied intentionally, e.g. as immune adjuvants, drug carriers or ion exchangers. The discovery that a wide range of nano- and microparticles share the capacity to induce IL-1β secretion via activation of the NLRP3 inflammasome in dendritic cells and macrophages has led to the hypothesis that nano- and microparticles may contribute in a uniform mechanistic manner to different disease entities. Other molecular mechanisms triggered by a range...
