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Mechanobiology
Over recent years, there has been increasing interest in the fundamental role played by local mechanical parameters in chondrocyte regulation and cartilage dysfunction as a first step in the development of osteoarthritis. This is how the idea of mechanobiology and the concept of mechanotransduction were born in the 90's. Indeed, a broad diversity of physiological phenomena is induced by mechanical stimuli (hearing, orientation to gravity, touch, tissue remodeling...) but the mechanism by which mechanical forces may regulate a physiological response is still unknown. In other respects, the concept of regenerative medicine has recently developed in parallel to this. Regenerative medicine is an...
Cells and Biomaterials for Intervertebral Disc Regeneration
Disorders related to the intervertebral disc (IVD) are common causes of morbidity and of severe life quality deterioration. IVD degeneration, although in many cases asymptomatic, is often the origin of painful neck and back diseases. In Western societies IVD related pain and disability account for enormous health care costs as a result of work absenteeism and thus lost production, disability benefits, medical and insurance expenses. Although only a small percentage of patients with disc disorders finally will undergo surgery, spinal surgery has been one of the fastest growing disciplines in the musculoskeletal field in recent years. Nevertheless, current treatment options are still a matter ...
Nonfusion Technologies in Spine Surgery
Written by an international group of expert spine surgeons, this volume thoroughly examines new nonfusion technologies for treating spinal degenerative conditions while preserving motion. Major sections describe various surgical techniques and devices for nucleus pulposus replacement and total lumbar and cervical disc arthroplasty, as well as other stabilization techniques. Coverage includes indications and contraindications, surgical approaches, and the latest clinical trial results. Several chapters discuss nonsurgical and minimally invasive treatments, including gene therapy, nucleus pulposus regeneration, and IDET. Other chapters address economic and ethical issues, including use of registries, medical device regulation, and outcome and cost of lumbar disc replacement versus lumbar fusion.
AOSpine Masters Series, Volume 8: Back Pain
Current statistics indicate that 75-80% of people worldwide will experience some form of back pain during their lifetime. Lumbar pain is a leading cause of disability - a global public health burden with serious economic implications. Written by internationally renowned spine experts, the 8th volume in the AOSpine Masters series is a concise, state-of-the-art overview on fundamental management strategies and current issues and challenges. The text covers the full age spectrum - from childhood to older adulthood - and contributing factors such as the sacroiliac joints, genetics, and spine infections. Clinical evaluation, treatment options, recent research advances, and future perspectives are...
Mechanisms and Models in Rheumatoid Arthritis
Rheumatoid arthritis is a bewilderingly complex disease involving the interactions of many, and varied, cell populations and multiple families of low and high molecular mass mediators. We are only slowly beginning to understand the mechanisms that produce the local and systematic pathology clinically recognized as rheumatoid arthritis. Increasingly, use is being made of experimental models of this disease in an effort to test hypotheses about putative pathological mechanisms and to investigate the effect of novel therapeutic agents. A major section of this book covers these experimental models in great detail from their development through to reviews of the most recent information on each mo...
Clinical Translation and Commercialisation of Advanced Therapy Medicinal Products
Dr. Yves Bayon is a Senior Principal Scientist at Medtronic and Dr. Alain Vertes is affiliated with NxR Biotechnologies GmbH. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Tissue Engineering and Regenerative Medicine
Through the integration of strategies from life science, engineering, and clinical medicine, tissue engineering and regenerative medicine hold the promise of new solutions to current health challenges. This rapidly developing field requires continual updates to the state-of-the-art knowledge in all of the aforementioned sciences. Tissue Engineering and Regenerative Medicine: A Nano Approach provides a compilation of the important aspects of tissue engineering and regenerative medicine, including dentistry, from fundamental principles to current advances and future trends. Written by internationally renowned scientists, engineers, and clinicians, the chapters cover the following areas: Nanobi...
Transactions of the Annual Meeting of the Orthopaedic Research Society
Consists of the transactions of the 22nd- annual meeting of the society.
Biologic Foundations for Skeletal Tissue Engineering
Tissue engineering research for bone and joint applications entails multidisciplinary teams bringing together the needed expertise in anatomy, biology, biochemistry, pathophysiology, materials science, biomechanics, fluidics, and clinical and veterinary orthopedics. It is the goal of this volume to provide students and investigators who are entering this exciting area with an understanding of the biologic foundations necessary to appreciate the problems in bone and cartilage that may benefit from innovative tissue engineering approaches. This volume includes state-of-the-art information about bone and cartilage physiology at the levels of cell and molecular biology, tissue structure, develop...
