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The Eukaryotic Replisome: a Guide to Protein Structure and Function
High-fidelity chromosomal DNA replication underpins all life on the planet. In humans, there are clear links between chromosome replication defects and genome instability, genetic disease and cancer, making a detailed understanding of the molecular mechanisms of genome duplication vital for future advances in diagnosis and treatment. Building on recent exciting advances in protein structure determination, the book will take the reader on a guided journey through the intricate molecular machinery of eukaryotic chromosome replication and provide an invaluable source of information, ideas and inspiration for all those with an interest in chromosome replication, whether from a basic science, translational biology and medical research perspective.
Retinal and Choroidal Angiogenesis
This book provides a comprehensive, in-depth review of our current understanding of the growth of blood vessels within the eye. Novel therapeutic strategies for the treatment of ocular angiogenesis are discussed, as are the unique challenges presented by delivery of drugs to the eye. The book emphasizes basic principles rather than specific experimental results, although recently acquired data is frequently cited to illustrate points of broader theoretical significance.
lncRNAs in Cancer Metastasis and Therapy Resistance
lncRNAs (long non-coding RNAs) are the relatively longer (more than 200 nucleotides long) subtypes of ncRNAs (non-coding RNAs) i.e the RNAs that do not code for any proteins. However, even without themselves being translated, lncRNAs impact the cellular gene expressions and functions in ways that are just beginning to be explored. The metastasis of human cancers as well as acquired resistance against the administered therapeutics are two major factors responsible for the cancer-associated mortality.
A Memorial to Thomas Tolson (1815-1854).
Thomas Tolson was born in England, in 1815, and came to America in 1843.
The Descendants of John Eby Hershey and Anna Mellinger Hershey
A genealogy of the descendants of John Eby Hershey born 16 Jan 1830 in Paradise Township, Pennsylvania the son of Jacob and Elizabeth Eby Hershey. He married 3 Jan 1854 Anna Mellinger.
