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Growth Hormone Therapy in Pediatrics
For 20 years, KIGS (Pfizer International Growth Database) has provided an outstanding tool for monitoring the use, efficacy and safety of growth hormone (GH) treatment in children with short stature of varying origin. This volume offers a comprehensive update of the continuing experiences in KIGS and is based on data from more than 50 countries and more than 60,000 patients. International experts analyse in detail the basic auxological characteristics of patients and their response to GH treatment for a broad spectrum of growth disorders. These include idiopathic GH deficiency, organic GH deficiency due to a variety of causes such as congenital malformations and syndromes, genetic disorders ...
Diagnostics of Endocrine Function in Children and Adolescents
A multitude of new developments, not only in the rapidly advancing field of molecular genetics and steroid metabolism but in all traditional areas of pediatric endocrinology, have influenced the diagnostic approach in children and adolescents with endocrine disorders, thus warranting this 4th, revised and extended edition of 'Diagnostics of Endocrine Function in Children and Adolescents'. Several chapters have been revised completely and all have been thoroughly updated. In addition, new chapters dealing with the muscle-bone unit and bone metabolism have also been incorporated. The original format of the chapters, which are a combination of in-depth discussion of the diagnostic process, prac...
Hormones and Neural Development
Steroids and other hormones act on the nervous systems throughout life to alter the growth and function of neural circuits. In some cases, hormones are responsible for major organization or re-organization of these circuits. This special issue is a series of invited reviews that summarize recent advances in research using diverse vertebrate and invertebrate model systems. The reviews focus on the functional role of steroid hormones that are synthesized de novo in neural tissue, the cellular and molecular mechanisms of steroid hormone action, the mechanisms by which hormones induce and regulate plastic changes in the nervous system at various life stages, the environmental regulation of hormonal action, the mechanisms of sexual differentiation, and steroidal modulation of adult behavior. The diversity of neural systems employed in these studies underscores the important perspectives that come from the investigation of both mammalian and non-mammalian model systems. The issue will serve as an important reference for anyone interested in hormonal regulation of neural and behavioral development.
Turner Syndrome
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