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Prevention of Bone Metastases
Bone metastases continue to be a major cause of morbidity in cancer patients, but improved understanding of the biology of bone metastases has led to the identification of drugs that are of potential value in not only their treatment but also their prevention. This book, written by recognized experts in the field, provides a detailed overview of current knowledge on this subject. One important focus of the book is the efficacy of bisphosphonates in preventing bone metastases in patients with breast, lung, and prostate cancer and disease progression in cases of multiple myeloma. The combined use of bisphosphonates and cytostatics is also discussed, with a report on first clinical data. Further topics addressed include the significance of the bone microenvironment, special issues in the elderly patient, the use of bone turnover markers, and initial findings obtained with denosumab.
You are not alone: DIAGNOSIS: BREAST CANCER
Diagnosis breast cancer – now what? Suddenly everything has changed – the diagnosis breast cancer pulls the rugout from under thousands of women and increasingly many men as well. The first reactions are shock and fear. Many people have no idea how to cope with the strain that such a diagnosis brings with it. Along with the mountain of emotions which must be dealt with in such a situation, the patients find themselves challenged to take the right steps for receiving optimal treatment: turn to someone you can trust – but to whom? This book would like to guide patients and those close to them on their journey out of this disease. It is not only clear answers to all questions concerning diagnosis, finding and treatment that help, but also narratives from the experience of breast cancer patients and expert opinions of renowned researchers and physicians concerning the treatment and curing of breast cancer that give competent information.
Frontiers in Oncology Breast Cancer Awareness Month, Special Edition
Foreword from the Editors: The start of October marks the commencement of Breast Cancer Awareness month, an annual month-long event to raise awareness and express support for those that have been affected by breast cancer in one way or another. Thanks to the incredible work and efforts by the scientific community, we have greatly enhanced our ability to detect breast cancer in its earliest stages, and have been able to develop simple routine screening techniques to ensure that everyone, even those in areas where resources are scarce, can identify early signs of a tumor forming. Our ability to treat breast cancer has greatly improved, becoming more sophisticated and precise. The advent of sta...
Oncoplastic Breast Surgery
The initial idea to write a book on oncoplastic techniques was raised through a meeting on breast cancer treatment in Saalfelden, A- tria two years ago. Contrary to the rather minor role breast surgery is conceded today compared to other treatment modalities the s- geons role on the further outcome of the disease is crucial and never compensated by radiation or adjuvant therapy. Whereas surgery a decade ago was merely excision of the cancer and closure of the wound leaving behind a mutilated breast in many women, the advent of oncoplastic surgery completely changed the modern surgical approach to breast cancer. The concept of oncoplastic breast surgery combines oncologic - mor resection - ei...
New Approaches to Classification and Diagnostic Prediction of Breast Cancers
Despite many years of translational research in breast cancer, very few new biomarkers have been implemented for clinical use beyond estrogen receptor, progesterone receptor, and HER2. The main reason is that many promising biomarkers are clinically validated but lack analytical and clinical utility. One explanation is that proper validation of the predictive ability of the biomarker in independent datasets, and with a pre-planned statistical analysis, is not always performed. Thus, there is a need to identify new biomarkers or new ways to subclassify breast cancer patients that are reproducible and easy to implement in the clinical setting but, more importantly, that improve patient’s outcomes.
