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Fundamentals of General Surgery
This book provides a comprehensive guide to the surgical skills required during general surgery. General Concepts are covered with descriptions of basic terminology, the logic behind specific approaches, limitations of specific skills, technical and practical considerations, and safety of using specific approaches and skills. More advanced topics including gastro-intestinal anastomosis, exploring a patient after a major trauma, and managing crisis situations are also discussed, as well as current controversies and future directions within general surgery. Fundamentals of General Surgery is relevant to trainees in general surgery and its subspecialties, and aims to give them an easy to access resource that contains real life examples, iconography, and recommended further reading.
New Antibiotic Targets
This book examines specific techniques which can be used to explore new drug targets and the effectiveness of new antibiotics. By testing new antimicrobial agents and modified existing drugs, the most vulnerable cell processes, such as cell wall and membrane synthesis, DNA replication, RNA transcription and protein synthesis, can be better exploited. This in-depth volume, however, delves even deeper by identifying additional novel cellular targets for these new therapies. The book will provide laboratory investigators with the vital tools they need to test the antimicrobial potential of products and to curb the rise of so many infectious diseases.
Microbial Genomics and Drug Discovery
Exploring innovative routes of drug discovery in the postgenomic era, Microbial Genomics and Drug Discovery examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates. The book discusses potential pathways for effective infection control, inhibition of antibacterial resistance, and acceleration of the drug discovery process. This comprehensive reference describes procedures to recognize common targets in various bacterial species for the design of broad-spectrum antibiotics and clearly illustrates the use of pathway tools in a genomics-based drug discovery project.
Antibiotic Discoveries and a Century of Creating Superbugs
In the pre-antibiotic era, the infections we currently see as relatively minor were sometimes deadly. This book discusses the rise (and sometimes fall) of “wonder drugs” designed to combat infections for which, at the time, there was no cure. However, history has shown us that, when antibiotics are overused, it can ultimately lead to either widespread discontinuation of the antibiotic or a drastic decrease in efficacy, leaving healthcare providers with few or no options for treatment. This book explores the discoveries of the major antibiotic drug classes, and highlights major bacterial strains which have become resistant and now represent difficult-to-treat infections. Barriers to new antibiotic development, as well as novel strategies for treating bacterial infections, are also explored.
Antimicrobials
Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the “arms race” with resistant pathogens. This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed.
Stuart Gordon
Animated by a singularly subversive spirit, the fiendishly intelligent works of Stuart Gordon (1947–2020) are distinguished by their arrant boldness and scab-picking wit. Provocative gems such as Re-Animator, From Beyond, Dolls, The Pit and the Pendulum, and Dagon consolidated his fearsome reputation as one of the masters of the contemporary horror film, bringing an unfamiliar archness, political complexity, and critical respect to a genre so often bereft of these virtues. A versatile filmmaker, one who resolutely refused to mellow with age, Gordon proved equally adept at crafting pointed science fiction (Robot Jox, Fortress, Space Truckers), sweet-tempered fantasy (The Wonderful Ice Cream...
Failed Anti-Reflux Therapy
Comprehensive and up-to-date analysis of GERD Has focus on remedies to failed treatment of the disease
