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Vitamins - especially B- and D-vitamins - influence the development and outcome of many neurodegenerative and other diseases. Among others, dementia, neural tube defects, epilepsy, and osteoporoses can be caused by vitamin deficiency. This book provides up-to-date knowledge on the role of water and fat soluble vitamins in the prevention of human diseases. Having knowledge about the association of vitamins and disease, as well as keeping track on the patients vitamin status has become increasingly important to every physician and clinical chemist.
1988 wurde die erste Phase III-Studie mit Interferon-ß1b begonnen – revolutionär ob ihres Studiendesigns, welches den Standard für alle weiteren Phase III-Studien bei Multipler Sklerose (MS) bis zum heutigen Tag begründete, revolutionär aber auch wegen der nachfolgenden Zulassung von Interferon-ß1b im Jahr 1993 als erste krankheitsmodifizierende Therapie bei MS und wegen des Enthusiasmus und der Innovation, die diese erfolgreiche Studie über die letzten zwei Jahrzehnte auslöste und prägte. Diese Pionierleistung, die MS-Patienten und Ärzte aus dem therapeutischen Nihilismus herausführte, und die Erfolgsgeschichte von Interferon-ß 1b, mit all den oft nicht mehr bewussten oder erinnerlichen, dafür umso grundlegenderen und weitreichenderen Einflüssen auf die wissenschaftlichen Erkenntnisse zur MS und ihrer Therapie, werden von namhaften MS-Experten aus Deutschland, Österreich und der Schweiz erstmals umfassend in einem Buch für Neurologen und an MS interessierten Ärzte zusammengefasst.
This book constitutes the refereed proceedings of the 16th International Conference on Artificial Intelligence in Education, AIED 2013, held in Memphis, TN, USA in July 2013. The 55 revised full papers presented together with 73 poster presentations were carefully reviewed and selected from a total of 168 submissions. The papers are arranged in sessions on student modeling and personalization, open-learner modeling, affective computing and engagement, educational data mining, learning together (collaborative learning and social computing), natural language processing, pedagogical agents, metacognition and self-regulated learning, feedback and scaffolding, designed learning activities, educational games and narrative, and outreach and scaling up.
The 10th International Conference on Intelligent Tutoring Systems, ITS 2010, cont- ued the bi-annual series of top-flight international conferences on the use of advanced educational technologies that are adaptive to users or groups of users. These highly interdisciplinary conferences bring together researchers in the learning sciences, computer science, cognitive or educational psychology, cognitive science, artificial intelligence, machine learning, and linguistics. The theme of the ITS 2010 conference was Bridges to Learning, a theme that connects the scientific content of the conf- ence and the geography of Pittsburgh, the host city. The conference addressed the use of advanced technolog...
This book constitutes the refereed proceedings of the 15th International Conference on Artificial Intelligence in Education, AIED 2011, held in Auckland, New Zealand in June/July 2011. The 49 revised full papers presented together with three invited talks and extended abstracts of poster presentations, young researchers contributions and interactive systems reports and workshop reports were carefully reviewed and selected from a total of 193 submissions. The papers report on technical advances in and cross-fertilization of approaches and ideas from the many topical areas that make up this highly interdisciplinary field of research and development including artificial intelligence, agent technology, computer science, cognitive and learning sciences, education, educational technology, game design, psychology, philosophy, sociology, anthropology and linguistics.
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Wilson Disease provides a comprehensive guide on this inherited genetic disorder that has devastating consequences for both the liver and neurologic/psychiatric health. This disease is of increasing interest to neurologists, hepatologists, and geneticists, but when the disease is diagnosed early, it is treatable, with patients living normal lives. This volume describes the molecular pathophysiology of WD and the clinical and pathological effects of copper. Separate sections address both diagnosis and medical and surgical approaches to treatment. Both adult and pediatric perspectives on diagnosis and treatment are addressed, and a section on genetics highlights advances in molecular diagnosti...
Johannes Vermeer, one of the greatest Dutch painters and for some the single greatest painter of all, produced a remarkably small corpus of work. In Vermeer's Family Secrets, Benjamin Binstock revolutionizes how we think about Vermeer's work and life. Vermeer, The Sphinx of Delft, is famously a mystery in art: despite the common claim that little is known of his biography, there is actually an abundance of fascinating information about Vermeer’s life that Binstock brings to bear on Vermeer’s art for the first time; he also offers new interpretations of several key documents pertaining to Vermeer that have been misunderstood. Lavishly illustrated with more than 180 black and white images ...