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Biologists and radiotherapists present their experimental work and clinical data in the field of radiation injuries of normal tissues and organs. Particular regard is payed to the relevance of biological mechanisms in clinical situations. Principles of radiation damage and combined treatment toxicity in radio-chemotherapy are being explained. The main topics discussed are the importance of microvasculature, time, doseand fractionation and factors modifying clinical radioresponse for early andlate radiation effects. Tissues and organs considered in this volume are mucosa and skin, lung and heart, bladder and muscle, CNS and eye. Special problems of pediatric radiotherapy, TBI, IORT and second malignacies are also mentioned.
This book reviews the state of the art presented by highly competent authors. The first two chapters are dedicated to clinical aspects of early diagnosis of important tumor types such as cervical cancer, breast cancer, cancer of the prostate and transitional cell carcinoma, skin cancer and melanoma, cancer of the oral cavity, esophagus, stomach and colon, and hematological malignancies. In the following chapters the value of the different methodological approaches to early detection of cacner are reviewed: tomor markers, imaging procedures, histo- and cytopathology, cytogenetic and molecular genetic methods. The book is of interest to all physicians, to researchers who accept the challenge to improve early detectin of cancer, and to governmental or charity institutions designing and supporting screening programs for early detectionof cancer.
Almost a century ago Paul Ehrlich introduced the "magic bullet" concept of targeting therapeutic agents to specific tissues in order to reduce systemic toxicity. Due to the advances in hybridoma technology in the 1980s, monoclonal antibodies (MAbs) with their exquisite affinity to tumor antigens have become powerful tools in the treatment of cancer, especially when linked to therapeutic agents such as radionuclides, drugs, toxins, or enzymes. It can now be expected that such agents will lead to new cancer treatments with high therapeutic success rates. However, there are major problems in developing this therapeutic concept to a routine treatment modality. This is partly due to factors such ...
Physicians and biologists here present their experimental work in the field of hyperthermia, paying particular regard to its relevance in clinical situations. Principles of heat action and combined treatment modalities are explicated. The main topics discussed are the effects of such treatment on normal tissues, animal tumors, malignant cell lines and human tumors.
This interdisciplinary approach is reflected in the broad scope of this volume, which aims to provide an overview of current treatment strategies for bladder and prostate cancer. The first part of the book discusses the optimization of radiation techniques like 3D planning or IMRT and focuses on definitive radiotherapy with or without adjuvant or neoadjuvant hormonal manipulation. The quality of life after therapy is another important issue. Further chapters deal with radical cystectomy and organ preservation by radio-chemotherapy as well as the treatment of T1G3 cancer. In the last part, the emphasis lies on brachytherapy, which has become increasingly important for the treatment of prostate cancer. This book will be of great value to urologists and radiation oncologists as well as to all others involved in the care of patients with urologic cancer.
First multi-year cumulation covers six years: 1965-70.
Age-related macular degeneration (ARMD) is a frequent disease of the elderly and the most common cause of blindness. Recently, various new treatment options have become available for ARMD. This book, written by recognized experts and including the results of international study groups, provides a comprehensive report on these treatments, documenting their rationale, uses, side-effects, and benefits. It will be of immense value to all with an interest in ARMD.
With contributions by numerous experts