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Antibiotic Discovery and Development
This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
Iatrogenic Gastrointestinal Complications
The purpose of this series of volumes is to present a comprehensive view of the complications that result from the use of acceptable diagnostic and therapeutic procedures. Individual volumes will deal with iatrogenic complications involving (1) the alimentary system, (2) the urinary system, (3) the respiratory and cardiac systems, (4) the skeletal system and (5) the pediatric patient. The term iatrogenic, derived from two Greek words, means physician-induced. Originally, it applied only to psychiatric disorders generated in the patient by autosuggestion, based on misinterpretation of the doctor's attitude and com ments. As clinically used, it now pertains to the inadvertent side-effects and ...
Secure Coding in C and C++
Learn the Root Causes of Software Vulnerabilities and How to Avoid Them Commonly exploited software vulnerabilities are usually caused by avoidable software defects. Having analyzed tens of thousands of vulnerability reports since 1988, CERT has determined that a relatively small number of root causes account for most of the vulnerabilities. Secure Coding in C and C++, Second Edition, identifies and explains these root causes and shows the steps that can be taken to prevent exploitation. Moreover, this book encourages programmers to adopt security best practices and to develop a security mindset that can help protect software from tomorrow’s attacks, not just today’s. Drawing on the CERT...
Critical Code
Critical Code contemplates Department of Defense (DoD) needs and priorities for software research and suggests a research agenda and related actions. Building on two prior booksâ€"Summary of a Workshop on Software Intensive Systems and Uncertainty at Scale and Preliminary Observations on DoD Software Research Needs and Prioritiesâ€"the present volume assesses the nature of the national investment in software research and, in particular, considers ways to revitalize the knowledge base needed to design, produce, and employ software-intensive systems for tomorrow's defense needs. Critical Code discusses four sets of questions: To what extent is software capability significant for the DoD? Is it becoming more or less significant and strategic in systems development? Will the advances in software producibility needed by the DoD emerge unaided from industry at a pace sufficient to meet evolving defense requirements? What are the opportunities for the DoD to make more effective use of emerging technology to improve software capability and software producibility? In which technology areas should the DoD invest in research to advance defense software capability and producibility?
Radio Voices
Looks at the history of radio broadcasting as an aspect of American culture, and discusses social tensions, radio formats, and the roles of African Americans and women
Fundamentals of Electromagnetics with MATLAB
Accompanying CD-ROM contains a MATLAB tutorial.
Free Energy Calculations
Free energy constitutes the most important thermodynamic quantity to understand how chemical species recognize each other, associate or react. Examples of problems in which knowledge of the underlying free energy behaviour is required, include conformational equilibria and molecular association, partitioning between immiscible liquids, receptor-drug interaction, protein-protein and protein-DNA association, and protein stability. This volume sets out to present a coherent and comprehensive account of the concepts that underlie different approaches devised for the determination of free energies. The reader will gain the necessary insight into the theoretical and computational foundations of th...
Machine Translation and the Information Soup
Machine Translation and the Information Soup! Over the past fty years, machine translation has grown from a tantalizing dream to a respectable and stable scienti c-linguistic enterprise, with users, c- mercial systems, university research, and government participation. But until very recently, MT has been performed as a relatively distinct operation, so- what isolated from other text processing. Today, this situation is changing rapidly. The explosive growth of the Web has brought multilingual text into the reach of nearly everyone with a computer. We live in a soup of information, an increasingly multilingual bouillabaisse. And to partake of this soup, we can use MT systems together with more and more tools and language processing technologies|information retrieval engines, - tomated text summarizers, and multimodal and multilingual displays. Though some of them may still be rather experimental, and though they may not quite t together well yet, it is clear that the future will o er text manipulation systems that contain all these functions, seamlessly interconnected in various ways.
Expanded Cinema
Fiftieth anniversary reissue of the founding media studies book that helped establish media art as a cultural category. First published in 1970, Gene Youngblood’s influential Expanded Cinema was the first serious treatment of video, computers, and holography as cinematic technologies. Long considered the bible for media artists, Youngblood’s insider account of 1960s counterculture and the birth of cybernetics remains a mainstay reference in today’s hypermediated digital world. This fiftieth anniversary edition includes a new Introduction by the author that offers conceptual tools for understanding the sociocultural and sociopolitical realities of our present world. A unique eyewitness ...
