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Revolutions in Human Biospecimen Study: Leveraging new technologies to explore the pathology, therapeutics and biomarkers for atherosclerotic disease
Over the last few years, new high-throughput biotechnologies are revolutionizing our ways to utilize human biospecimens for understanding atherosclerotic disease. These recent advances allow deep profiling of individual cells at the genomics, epigenomics, transcriptomics and proteomics levels, or even simultaneous detection of various combinations of ‘Omics’ in the same cell. Additionally, novel methods to integrate data at different levels from tissue sections and dissociated tissues are the emerging trends in large and institutional biobank studies. Growing literature has shown the value of such sequencing and bioinformatic strategies in shedding light on (1) how risk genes, as identified by the Genome-Wide Association Study, contribute to atherogenesis (genotype to phenotype), and (2) how features of atherosclerotic lesions affect patient response in clinical trials (phenotype to the clinical outcome). The hybrid of cutting-edge biotechnologies and bioinformatic approaches helps us maximize biobank resources to accelerate bench-to-bedside research.
Interplay Between Diets, Microbiota, Bacterial Metabolites and Host for Intestinal Health and Disease
An interplay between the diet and the microbiota appears to regulate the host responses. It is now well acknowledged that the microbiota and their metabolites such as short chain fatty acids, bile acids, etc modulates the metabolic status, educates the host’s intestinal immune system, and protects the host against invading pathogens and injury. Concomitantly, environmental factors such as diets and dietary components play a major role in shaping the microbiota, thereby modulating the host immune and epithelial responses, and ultimately directing the individual’s health status. Disruption in any of these elements or their interactions have been linked to the development and progression of...
AHA Scientific Sessions 2019 - Final Program
The American Heart Association’s Scientific Sessions 2019 is bringing big science, big technology, and big networking opportunities to Philadelphia, Pennsylvania this November. This event features five days of the best in science and cardiovascular clinical practice covering all aspects of basic, clinical, population and translational content.
Rethinking History, Reframing Identity
This book contributes to the theoretical and methodological discussion about how the diverging experiences of generations and their historical memories play a role in the process of national identity formation. Drawing from narratives gathered within the Ukrainian minority in northern Poland and centered on the collective trauma of Action Vistula, where in 1947 about 140,000 Ukrainians were resettled from south-eastern Poland and relocated to the north-western areas, this study shows that three generations vary considerably with regard to their understandings of home, integration, history and religion. Thus, generational differences are an essential element in the analysis and understanding of social and political change. The findings of this study provide a contribution to debates about the process based nature of national identity, the role of trauma in creating generational consciousness and how generations should be conceptualized.
The Cenotes of the Riviera Maya 2016
A complete guide to snorkeling, cavern, and cave diving the cenotes of the Riviera Maya. This book includes photographs, maps, and provides details of where and how to swim, dive, and enjoy these beautiful cenotes located on the Caribbean coast of Mexico's Yucatan Peninsula.
