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Antimicrobial Agents and Intracellular Pathogens is the first book devoted to the relationships among intracellular pathogens, antibiotics, and cells. The book is divided into two sections. Part One describes the effects of antibiotics on uninfected and infected phagocytic cells, the subcellular location of antibiotic compounds, the subcellular compartment of intracellular microorganisms multiplication, and the vectorization of antibiotics. Part Two focuses on intracellular pathogens used as paradigms, including strict intracellular bacteria and antibiotics such as Chlamydia, Rickettsia, Ehrlichia, and Coxiella burnetii; facultative intracellular bacteria and antibiotics such as Legionella and Mycobacteria; and intracellular protozoa and antimicrobial agents, such as Leishmania, Trypnonosoma, and Toxoplasma. This book will be an important reference for microbiologists, clinical microbiologists, infectious disease experts, and researchers in pharmaceutical companies involved in antibiotic development.
Why do some elites survive while others do not? How do certain institutions manage to preserve their importance in the face of crises, instability, and change? How does a democratic society legitimize elitist institutions? Combining the use of important social theories—particularly those of Mosca, Schumpeter, Tocqueville, and Pareto—with empirical analysis, Ezra Suleiman tries to answer these questions in his examination of the dominance and stability of France's governing elites. The author draws on original survey data, historical evidence, and specialized documentary sources. His three part discussion deals, first, with the state institutions that nurture the French elite; second, wit...
"In the late 1960s, France attempted a complete overhaul of its financial regulations without being forced to do so by a stock market crash or the collapse of its banking system. Out of pure political expediency, Gaullist reformers seized the opportunity offered by a minor insider trading case to establish the "Commission des Opérations de Bourse (COB), an independent commission in charge of regulating the securities market. Even more surprisingly, these staunch defenders of national sovereignty drew their inspiration from an American model, the Securities and Exchange Commission. Rather than a comparative study of securities regulation in France and the United States, the book is an investigation of the dynamics of policy transfer in the field of securities regulation. Along the way, it reveals a great deal about French and American perceptions of morality and capitalism, but also, more generally, about the exercise of political power in modern democracies, the interaction between business and government, and the mechanisms of institutional innovation"--
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In recent decades, alternatives to the established bubonic-plague theory have been presented as to the microbiologcal identity and mechanism(s) of spread of historical plague epidemics. In this monograph, the six important alternative theories are intensively discussed in the light of the historical sources, the central primary studies and standard works on bubonic plague and the alternative microbiological agents, insofar as they are testable. These seven theories are incompatible and at least six of them must be untenable. In the author’s opinion, the arguments against the bubonic-plague theory and for all alternative theories are untenable. This monograph therefore also has been written also as a standard work on bubonic plague, giving a broad and in-depth presentation of the medical, epidemiological and historical evidence and the methodological tenets for identification of historical diseases by comparison with modern medical knowledge.
Network research has recently been adopted as one of the tools of the trade in archaeology, used to study a wide range of topics: interactions between island communities, movements through urban spaces, visibility in past landscapes, material culture similarity, exchange, and much more. This Handbook is the first authoritative reference work for archaeological network research, featuring current topical trends and covering the archaeological application of network methods and theories. This is elaborately demonstrated through substantive topics and case studies drawn from a breadth of periods and cultures in world archaeology. It highlights and further develops the unique contributions made by archaeological research to network science, especially concerning the development of spatial and material culture network methods and approaches to studying long-term network change. This is the go-to resource for students and scholars wishing to explore how network science can be applied in archaeology through an up-to-date overview of the field.
Described as "a golden age of pathogens", the long fifteenth century was notable for a series of international, national and regional epidemics that had a profound effect upon the fabric of society. The impact of pestilence upon the literary, religious, social and political life of men, women and children throughout Europe and beyond continues to excite lively debate among historians, as the ten papers presented in this volume confirm. They deal with the response of urban communities in England, France and Italy to matters of public health, governance and welfare, as well as addressing the reactions of the medical profession to successive outbreaks of disease, and of individuals to the omnipresence of Death, while two, very different, essays examine the important, if sometimes controversial, contribution now being made by microbiologists to our understanding of the Black Death.
This groundbreaking book charts the origins and spread of the systems movement. After World War II, a systems approach to solving complex problems and managing complex systems came into vogue among engineers, scientists, and managers, fostered in part by the diffusion of digital computing power. Enthusiasm for the approach peaked during the Johnson administration, when it was applied to everything from military command and control systems to poverty in American cities. Although its failure in the social sphere, coupled with increasing skepticism about the role of technology and "experts" in American society, led to a retrenchment, systems methods are still part of modern managerial practice....
In this volume, 12 scholars from various disciplines - have produced a comprehensive account of the pandemic's origins, spread, and mortality, as well as its economic, social, political, and religious effects.