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Diagnosis and Management of Mitochondrial Disorders
This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest. Further, it provides updated concepts on genotype-phenotype correlations, clinical syndromes, diagnostic algorithms and therapies. Written by the world’s foremost mitochondrial researchers, the book comprehensively presents the state-of-the-art in mitochondrial medicine, making it of interest to a wide variety of specialists, including neurologists, geneticists, internists and biologists.
Diseases of DNA Repair
Since this book is geared to be used by varied groups of readers such as advanced students and instructors in the fields of biology and medicine, scientists and more importantly clinicians, it is considered important to provide brief accounts of the basics of DNA damage, repair, mutagenesis and cancer. The purpose of this book is to present an updated detailed account of some important additional diseases of DNA repair. It has not been possible to cover all the DNA repair deficient diseases in this volume, hence diseases such as Bloom’s syndrome, Werner’s syndrome, Nijmegen breakage syndrome, ataxia telangiectasia‐like disorder, RA D 50 deficiency, RIDDLE syndrome and others will be presented in a forthcoming volume.
Sleight of Mind
John Jacobs, the last helioship captain old enough to remember technology, has lost his long-time partner and faces ruin if he fails to fly where no commercial liner has gone before: Venus. But space remains wild between Earth and Venus, and Jacobs must overcome space elementals, mysterious pursuers, and even Earth Navy firepower to survive. Journeyman wizard Donal Cuthbert must take that flight to root out the truth about a forming interplanetary shadow government. And stop that conspiracy, even if he learns that his girlfriend serves it. But gathering information requires more than spells, and may lead to a duel he can only lose. Force alone will not help them survive. It will take a little sleight of hand … and sleight of mind.
The Role of Mitochondria, Oxidative Stress and Altered Calcium Homeostasis in Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Treatments
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, devastating and fatal disease characterized by selective loss of upper and lower motor neurons of the cerebral cortex, brainstem, spinal cord and muscle atrophy. In spite of many years of research, the pathogenesis of ALS is still not well understood. ALS is a multifaceted genetic disease, in which genetic susceptibility to motor neuron death interacts with environmental factors and there is still no cure for this deleterious disease. At present, there is only one FDA approved drug, Riluzole which according to past studies only modestly slows the progression of the disease, and improves survival by up to three months. The sufferin...
Magician's Choice
Praise for Magician’s Choice “In the future of Magician's Choice, magic has displaced science, but magic takes as much rigor to operate as technology ever did. Stefon Mears weaves an entertaining space opera out of tuning forks, duels, and dragon familiars. The result is an impressive debut novel.” – Bruce Holland Rogers Author of The Keyhole Opera About Magician’s Choice Academic wizard Donal Cuthbert thought courier work would be easy money. But after someone tries to blow him up, Donal must navigate a web of lies, murders, and corporate espionage, including a beautiful liaison who might be his ally … or his greatest enemy. Helioship captain John Jacobs faces financial ruin unless this Mars-Earth run goes perfectly. But squabbling crew members, threats from deep space, and a passenger complement full of conspiracies might destroy his ship en route. Together Donal and Jacobs find themselves facing a choice … with the fate of worlds in the balance.
Motor Neuron Disease Research Progress
The motor neuron diseases (or motor neuron diseases) (MND) are a group of progressive neurological disorders that destroy motor neurons, the cells that control voluntary muscle activity such as speaking, walking, breathing, and swallowing. Neurological examination presents specific signs associated with upper and lower motor neuron degeneration. Signs of upper motor neuron damage include spasticity, brisk reflexes and the Babinski sign. Signs of lower motor neuron damage include weakness and muscle atrophy. Every muscle group in the body requires both upper and lower motor neurons to function. It is a common misconception that "upper" motor neurons control the arms, while "lower" motor neuro...
Regulatory Networks in Stem Cells
Stem cells appear to be fundamental cellular units associated with the origin of multicellular organisms and have evolved to function in safeguarding the cellular homeostasis in organ t- sues. The characteristics of stem cells that distinguish them from other cells have been the fascinating subjects of stem cell research. The important properties of stem cells, such as ma- tenance of quiescence, self-renewal capacity, and differentiation potential, have propelled this exciting ?eld and presently form a common theme of research in developmental biology and medicine. The derivation of pluripotent embryonic stem cells, the prospective identi?cation of multipotent adult stem cells, and, more rec...
