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Microbe
Microbe Microbe THIRD EDITION Brings the excitement, breadth, and power of the modern microbial sciences to the next generation of students and scientists. This third edition of the bestselling Microbe textbook is an eloquent and highly readable introduction to microbiology that will engage and excite science majors and pre-health professionals. The authors have carefully crafted a lively narrative with stunning, detailed illustrations to bring key concepts to life and promote a lifelong passion for the microbial sciences. Microbe is replete with case studies, ranging from a MRSA (methicillin-resistant Staphylococcus aureus) outbreak in an NFL locker room to the search for life outside of Ea...
Autophagy in Mammalian Systems, Part B
This is the companion volume to Daniel Klionsky's Autophagy: Lower Eukaryotes, which features the basic methods in autophagy covering yeasts and alternative fungi (aspergillus, podospora, magnaporthe). Klionsky is one of the leading authorities in the field. He is the editor-in-chief of Autophagy. The November 2007 issue of Nature Reviews highlighted his article, "Autophagy: From phenomenology to molecular understanding in less than a decade. He is currently editing guidelines for the field, with 230 contributing authors, that will publish in Autophagy.Particularly in times of stress, like starvation and disease, higher organisms have an internal mechanism in their cells for chewing up and r...
Legionella Pneumophila: Pathogenesis and Immunity
The volume brings together all of the latest research on this pathogen, the interest in which is rapidly growing. Legionella pneumophila is an emerging human pathogen that resides in natural environments as a parasite of freshwater. There have been major new developments in this field, including the publication of three whole genome sequences and the discovery of a developmental cycle and novel cyst-like highly infectious form.
Management of Legionella in Water Systems
Legionnaires' disease, a pneumonia caused by the Legionella bacterium, is the leading cause of reported waterborne disease outbreaks in the United States. Legionella occur naturally in water from many different environmental sources, but grow rapidly in the warm, stagnant conditions that can be found in engineered water systems such as cooling towers, building plumbing, and hot tubs. Humans are primarily exposed to Legionella through inhalation of contaminated aerosols into the respiratory system. Legionnaires' disease can be fatal, with between 3 and 33 percent of Legionella infections leading to death, and studies show the incidence of Legionnaires' disease in the United States increased five-fold from 2000 to 2017. Management of Legionella in Water Systems reviews the state of science on Legionella contamination of water systems, specifically the ecology and diagnosis. This report explores the process of transmission via water systems, quantification, prevention and control, and policy and training issues that affect the incidence of Legionnaires' disease. It also analyzes existing knowledge gaps and recommends research priorities moving forward.
Biology and Pathogenesis of Legionella
Legionella pneumophila was first isolated as the causative agent of a deadly infectious pneumonia at a convention of the American Legion forty years ago. Since then, Legionnaires’ disease continues to be a significant public health concern. Today, our understanding of the Legionella genus, comprising environmental bacteria and opportunistic human pathogens, has dramatically increased. The study of how pathogenic Legionella interact with host cells, both protozoan and mammalian, has not only taught us about host-pathogen interactions but has revealed novel and unexpected insights into human cell biology and immunology. The capacity of pathogenic Legionella to commandeer cellular processes s...
Flint Fights Back
An account of the Flint water crisis shows that Flint's struggle for safe and affordable water is part of a broader struggle for democracy. When Flint, Michigan, changed its source of municipal water from Lake Huron to the Flint River, Flint residents were repeatedly assured that the water was of the highest quality. At the switchover ceremony, the mayor and other officials performed a celebratory toast, declaring “Here's to Flint!” and downing glasses of freshly treated water. But as we now know, the water coming out of residents' taps harbored a variety of contaminants, including high levels of lead. In Flint Fights Back, Benjamin Pauli examines the water crisis and the political activ...
Emerging Concepts in Bacterial Biofilms
The ability to form biofilms is a universal attribute of bacteria. Bacteria are able to grow on almost every surface, forming these architecturally complex communities. In biofilms, the cells grow in multicellular aggregates, encased in an extracellular matrix produced by the bacteria themselves. They impact humans in many ways, and can form in natural, medical and industrial settings. For example, the formation of biofilms on medical devices such as catheters or implants often results in difficult-to-treat chronic infections. This book focuses on emerging concepts in bacterial biofilm research, such as the different mechanisms of biofilm formation in Gram negative and Gram positive bacteria, and the burden of biofilm associated infections. It also highlights the various anti-biofilm strategies that can be translated to curb biofilm-associated infections and the escalation of antimicrobial resistance determinants.
Microbe
Brings the excitement, breadth, and power of the modern microbial sciences to the next generation of students and scientists. This new edition of Microbe is an eloquent and highly readable introduction to microbiology that will engage and excite science majors and pre-health professionals. The authors, all prominent scientists, have carefully crafted this lively narrative to bring key microbiology concepts to life and promote a lifelong passion for the microbial sciences. Far more than a comprehensive reference book, Microbe is replete with case studies, ranging from sauerkraut fermentation to the cholera outbreak in Haiti, that illustrate the impact of key microbiology concepts on real-worl...
Microbial Modulation of Host Apoptosis and Pyroptosis
Infectious disease is the result of an interactive relationship between a microbial pathogen and its host. In this interaction both the host and the pathogen attempt to manipulate each other using a complex network to maximize their respective survival probabilities. Programmed host cell death is a direct outcome of host-pathogen interaction and may benefit host or pathogen depending on microbial pathogenesis. Apoptosis and pyroptosis are two common programmed cell death types induced by various microbial infections. Apoptosis is non-inflammatory programmed cell death and can be triggered through intrinsic or extrinsic pathways and with or without the contribution of mitochondria. Pyroptosis...
