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Understanding how cancer tumours develop and spread is vital for finding treatments and cures. Cancer Modelling and Simulation demonstrates how mathematical modelling and computer simulation techniques are used to discover and gain insight into the dynamics of tumour development and growth. It highlights the benefits of tumour modelling, such as discovering optimal tumour therapy schedules, identifying the most promising candidates for further clinical investigation, and reducing the number of animal experiments. By examining the analytical, mathematical, and biological aspects of tumour growth and modelling, the book provides a common language and knowledge for professionals in several disciplines.
This textbook, now in its fourth edition, offers a rigorous and self-contained introduction to the theory of continuous-time stochastic processes, stochastic integrals, and stochastic differential equations. Expertly balancing theory and applications, it features concrete examples of modeling real-world problems from biology, medicine, finance, and insurance using stochastic methods. No previous knowledge of stochastic processes is required. Unlike other books on stochastic methods that specialize in a specific field of applications, this volume examines the ways in which similar stochastic methods can be applied across different fields. Beginning with the fundamentals of probability, the au...
This book contains a collection of original research articles and review articles that describe novel mathematical modeling techniques and the application of those techniques to models of cell motility in a variety of contexts. The aim is to highlight some of the recent mathematical work geared at understanding the coordination of intracellular processes involved in the movement of cells. This collection will benefit researchers interested in cell motility as well graduate students taking a topics course in this area.
This monograph provides a comprehensive and self-contained treatment of continuum physics, illustrating a systematic approach to the constitutive equations for wide-ranging classes of materials. Derivations of results are detailed through careful proofs, and the contents have been developed to ensure a self-contained and consistent presentation. Part I reviews the kinematics of continuous bodies and illustrates the general setting of balance laws. Essential preliminaries to continuum physics – such as reference and current configurations, transport relations, singular surfaces, objectivity, and objective time derivatives – are covered in detail. A chapter on balance equations then develo...
It is widely recognized that the degree of development of a science is given by the transition from a mainly descriptive stage to a more quantitative stage. In this transition, qualitative interpretations (conceptual models) are complemented with quantification (numerical models, both, deterministic and stochastic). This has been the main task of mathematical geoscientists during the last forty years - to establish new frontiers and new challenges in the study and understanding of the natural world. Mathematics of Planet Earth comprises the proceedings of the International Association for Mathematical Geosciences Conference (IAMG2013), held in Madrid from September 2-6, 2013. The Conference addresses researchers, professionals and students. The proceedings contain more than 150 original contributions and give a multidisciplinary vision of mathematical geosciences.
This contributed volume explores innovative research in the modeling, simulation, and control of crowd dynamics. Chapter authors approach the topic from the perspectives of mathematics, physics, engineering, and psychology, providing a comprehensive overview of the work carried out in this challenging interdisciplinary research field. The volume begins with an overview of analytical problems related to crowd modeling. Attention is then given to the importance of considering the social and psychological factors that influence crowd behavior – such as emotions, communication, and decision-making processes – in order to create reliable models. Finally, specific features of crowd behavior are explored, including single-file traffic, passenger movement, modeling multiple groups in crowds, and the interplay between crowd dynamics and the spread of disease. Crowd Dynamics, Volume 4 is ideal for mathematicians, engineers, physicists, and other researchers working in the rapidly growing field of modeling and simulation of human crowds.
The chapters in this contributed volume showcase current theoretical approaches in the modeling of ocular fluid dynamics in health and disease. By including chapters written by experts from a variety of fields, this volume will help foster a genuinely collaborative spirit between clinical and research scientists. It vividly illustrates the advantages of clinical and experimental methods, data-driven modeling, and physically-based modeling, while also detailing the limitations of each approach. Blood, aqueous humor, vitreous humor, tear film, and cerebrospinal fluid each have a section dedicated to their anatomy and physiology, pathological conditions, imaging techniques, and mathematical mod...
This edited volume provides an essential resource for urban morphology, the study of urban forms and structures, offering a much-needed mathematical perspective. Experts on a variety of mathematical modeling techniques provide new insights into specific aspects of the field, such as street networks, sustainability, and urban growth. The chapters collected here make a clear case for the importance of tools and methods to understand, model, and simulate the formation and evolution of cities. The chapters cover a wide variety of topics in urban morphology, and are conveniently organized by their mathematical principles. The first part covers fractals and focuses on how self-similar structures s...
This book throws fresh light on a forgotten war that raged in the 1940s in the mountains of Spain. It is a story of heartbreak and heroism, relating the dramatic events in a village trapped between the ruthless Civil Guard and guerrillas led by a legendary chieftain named Roberto. Guerrilleros, villagers, Civil Guards give a poignant account of bloodshed, betrayal and courage. Historian Paul Preston comments: "As exciting as any thriller, yet deeply moving, it deserves to be read by everyone concerned with the history of contemporary Spain."