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GABA and Sleep
GABA (gamma-aminobutyric acid) is the main neurotransmitter regulating sleep. The majority of drugs presently in use for the treatment of sleep disorders act by enhancing GABAergic neuronal inhibition. The GABA system is, therefore, of prime clinical relevance for the therapy of insomnia. The focus of this volume is on the neuropsychopharmacology and the clinical impact of the GABA system in regulating sleep and wakefulness. It presents molecular, neuropharmacological, systems-biological and clinical approaches to the understanding of the mechanism of action of GABA and GABAergic drugs. It also explores the role of GABA in the basic drives that affect sleep, and the influences that adapt sleep and wakefulness to external events.
X Films
Filmmaker Alex Cox's thoughtful autobiography examines his craft and influences, as well as providing his insights into many of his favorite films. Sometimes called a radical, Cox is a quintessential auteur, as well as an internationally focused, insightful critic and writer whose passion for film has gripped him since childhood. In addition to being a captivating look into Cox's process, this book also encourages and instructs would-be independent filmmakers, guiding the next generation of film pioneers through the arduous journey of creation. Cox weaves his own "confessions" with his notes to the new guard, including thoughts on new forms of digital distribution and his radical views on intellectual property — the result is a readable, startling treatise on both the film innovations of today and the thrilling potential of future filmmaking.
Insomnia and beyond - Exploring the therapeutic potential of orexin receptor antagonists
Orexin/hypocretin neuropeptides, produced by a few thousand neurons in the lateral hypothalamus, are of critical importance for the control of vigilance and arousal of vertebrates, from fish to amphibians, birds and mammals. Two orexin peptides, called orexin-A and orexin-B, exist in mammals. They bind with different affinities to two distinct, widely distributed, excitatory G-protein- coupled receptors, orexin receptor type 1 and type 2 (OXR-1/2). The discovery of an OXR mutation causing canine narcolepsy, the narcolepsy-like phenotype of orexin peptide knockout mice, and the orexin neuron loss associated with human narcoleptic patients laid the foundation for the discovery of small molecul...
Functional Anatomy of the Sleep-Wakefulness Cycle: Wakefulness
Sleep is a necessary, active, diverse and periodic condition, homeostatically regulated and precisely meshed with waking time into the sleep-wakefulness cycle. The authors present a detailed and updated review of the structures involved in the phase of wakefulness, including their morphological, functional and chemical characteristics, as well as their anatomical connections
Cuban Fusion
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Entre a realidade e a ficção. Não sei exatamente se poderia categorizar a publicação como uma ficção, até mesmo pelo fato de que, cientificamente falando, as constatações que são apresentadas no livro foram alcançadas por meio de análises comparativas de fotografias oficiais e outras fontes astro amadoras, publicizadas na internet e abertamente disponíveis à investigação científica. Considerando que a base científica está fundada na observação, poderia afirmar que se trata de uma linha que busca reformular antigas questões e desmistificar alguns fenômenos, ainda cercados de teorias pseudocientíficas e conspiratórias. Restringindo o universo de suposições, orbitei ...
Forbidden Passages
During the sixteenth and seventeenth centuries, Spanish authorities restricted emigration to the Americas to those who could prove they had been Catholic for at least three generations. In doing so, they hoped to instill religious orthodoxy in the colonies and believed Muslim converts, or Moriscos, would hamper efforts to convert indigenous people to Catholicism. Nevertheless, Moriscos secretly made the treacherous journey across the ocean, settling in the forbidden territories and influencing the nature of Spanish colonialism. Once landed, Morisco men and women struggled to define and practice their religion or pursue their trades, all while experiencing increasing anxiety about their place...
The Gating and Maintenance of sleep and Wake: New Circuits and Insights
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Cinema of Solitude
La crisis, a period of political and economic turmoil in Mexico that began in the late 1960s, spawned a new era in Mexican cinema. Known as el Nuevo Cine (the New Cinema), these films presented alienated characters caught in a painful transition period in which old family, gender, and social roles have ceased to function without being replaced by viable new ones. These are the films explored by Charles Ramírez Berg in Cinema of Solitude, the first book-length critical study of Mexican cinema in English. Berg discusses the major films and filmmakers of el Nuevo Cine in depth. He analyzes dozens of commercial movies, from popular comedies and adventures to award-winning films. Introductory ch...
