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As expenditure on health care has increasingly become an area of public debate and concern, public and private health care decision-makers have called for more rigorous use of cost-benefit and cost-effectiveness analysis to guide spending. Concerns have arisen, however, about the overall quality of such analyses. This book discusses and evaluates best-practice methods of conducting cost-benefit and cost-effectiveness studies of pharmaceuticals and other medical technologies. It encompasses a wide variety of topics, ranging from measuring cost and effectiveness to discounting to the use of dynamic modelling of cost-effectiveness. The book also includes conceptual and practical aspects of cost-effectiveness analysis by researchers who have conducted applied research in these areas. Rarely does the book provide a singular solution to a measurement problem; rather, the reader is directed to choices among alternative approaches and an analysis of the advantages and disadvantages of each.
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When little spider Milton discovers he's been branded deadly on social media - and is targeted by pest-killers BugKILL - he fears for his life and the future of his species. He must clear his name, but is he mighty enough to achieve the impossible: convincing humankind?
A groundbreaking biography of Milton’s formative years that provides a new account of the poet’s political radicalization John Milton (1608–1674) has a unique claim on literary and intellectual history as the author of both Paradise Lost, the greatest narrative poem in English, and prose defences of the execution of Charles I that influenced the French and American revolutions. Tracing Milton’s literary, intellectual, and political development with unprecedented depth and understanding, Poet of Revolution is an unmatched biographical account of the formation of the mind that would go on to create Paradise Lost—but would first justify the killing of a king. Biographers of Milton hav...