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Parkinson's Disease
Parkinson's disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neuro...
Patlama Kayıtları
Yi Nehri ile Balou Sıradağları arasındaki vadide konumlanan Patlama köyü, bin yıl önce volkanik bir patlamadan kaçan göçmenler tarafından kurulmuştur. Gelgelelim Mao sonrası dönemde, burası küçük bir köyden uçsuz bucaksız bir metropole dönüşünce “patlama” ismi bambaşka bir anlam kazanır. Bu hızlı büyümenin ardında köyün önde gelen üç ailesi vardır: Kong biraderler, kasabanın eski muhtarının kızı Zhu Ying ve ilçe yöneticisi olarak başlayıp güçlü bir politikacı ve işadamına dönüşen Cheng Qing. Sadakat, aldatma, tutku ve ihtirastan oluşan güçlü bir ağla birbirine dolanan bu karakterler kasabanın süper güçlü bir şehre dönü...
The Explosion Chronicles
LONGLISTED FOR THE MAN BOOKER INTERNATIONAL 2017 With the Yi River on one side and the Balou Mountains on the other, the village of Explosion was founded a thousand years ago by refugees fleeing a volcanic eruption. But in the post-Mao era, the name takes on a new significance as the rural community grows explosively from a small village to a town to a city to a vast megalopolis. Behind this rapid expansion are three rival clans linked together by a web of ambition, madness and greed. Together they transform their hometown into a Babylon of modern times -- an unrivalled urban superpower built on lies, sex and thievery. 'One of the masters of modern Chinese literature' Jung Chang
Phenotyping of Human iPSC-derived Neurons
Phenotyping of Human iPSC-derived Neurons: Patient-Driven Research examines the steps in a preclinical pipeline that utilizes iPSC-derived neuronal technology to better understand neurological disorders and identify novel therapeutics, also providing considerations and best practices. By presenting example projects that identify phenotypes and mechanisms relevant to autism spectrum disorder and epilepsy, this book allows readers to understand what considerations are important to assess at the start of project design. Sections address reproducibility issues and advances in technology at each stage of the pipeline and provide suggestions for improvement. From patient sample collection and prop...
Combined Membership List
Lists for 19 include the Mathematical Association of America, and 1955- also the Society for Industrial and Applied Mathematics.
AACR 2019 Proceedings: Abstracts 1-2748
American Association for Cancer Research 2019 Proceedings: Abstracts 1-2748 - Part A
