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Gold Digger #244
Leprechaun Princess O'Lura has just received a nasty surprise from her father, King Shamus: All wee folk, Leprechauns included, are critically low on Sprinkles, a key element of their magic, and he forbids her to restock! Not wanting her people to face a less magical future when she eventually takes the throne, O'Lura takes a covert task force to find more -- but they're not the only ones!
Tox21 Challenge to Build Predictive Models of Nuclear Receptor and Stress Response Pathways as Mediated by Exposure to Environmental Toxicants and Drugs
Tens of thousands of chemicals are released into the environment every day. High-throughput screening (HTS) has offered a more efficient and cost-effective alternative to traditional toxicity tests that can profile these chemicals for potential adverse effects with the aim to prioritize a manageable number for more in depth testing and to provide clues to mechanism of toxicity. The Tox21 program, a collaboration between the National Institute of Environmental Health Sciences (NIEHS)/National Toxicology Program (NTP), the U.S. Environmental Protection Agency’s (EPA) National Center for Computational Toxicology (NCCT), the National Institutes of Health (NIH) National Center for Advancing Tra...
Transporters and Drug-Metabolizing Enzymes in Drug Toxicity
TRANSPORTERS AND DRUG-METABOLIZING ENZYMES IN DRUG TOXICITY Explore up-to-date coverage on the interaction between drug metabolism enzymes, transporters, and drug toxicity with this leading resources Transporters and Drug-Metabolizing Enzymes in Drug Toxicity delivers a comprehensive and updated review of the relationship between drug metabolism, transporters, and toxicity, providing insights into a major challenge in drug development – accurate assessment of human drug toxicity. Combining two disciplines frequently considered independently of one another, the book combines drug metabolism and toxicology with a focus on the role of biotransformation on drug toxicity and as a major factor f...
The Quintessence of Basic and Clinical Research and Scientific Publishing
The book, intended for biomedical researchers, attempts to foster a comprehensive understanding of the elements that impact scientific research, such as clinical trial design, communication, and publication methods. It introduces the process of idea generation and creative/critical thinking, leading to the development of key concepts that coalesce into theoretical constructs and working hypotheses. The book systematically delineates research phases associated with a bench-to-bedside translational approach, providing the full depth and breadth of drug discovery and development: design, synthesis, and optimization of drug candidates interacting with targets linked to diseases, as well as clini...
QSAR in Safety Evaluation and Risk Assessment
QSAR in Safety Evaluation and Risk Assessment provides comprehensive coverage on QSAR methods, tools, data sources, and models focusing on applications in products safety evaluation and chemicals risk assessment. Organized into five parts, the book covers almost all aspects of QSAR modeling and application. Topics in the book include methods of QSAR, from both scientific and regulatory viewpoints; data sources available for facilitating QSAR models development; software tools for QSAR development; and QSAR models developed for assisting safety evaluation and risk assessment. Chapter contributors are authored by a lineup of active scientists in this field. The chapters not only provide profes...
Archaeology and Conservation along the Silk Road
Supported by Eurasia Pacific Uninet, the second international conference on "Archaeology and Conservation along the Silk Road" was jointly organized by Nanjing University China and Institute of Conservation, University of Applied Arts Vienna and held in May 2016 in China. Silk Road showcases the trans-continental cultural movements between Europe and Asia and this event encouraged researchers to reflect on popular as well as otherwise under-represented topics. This volume includes selected papers from the conference and merges aspects of archaeology with conservation. Subjects vary from field drawings, unique local techniques, spread of diseases and epidemics to DNA studies assessing population migration and mixture. Next Silk Road conference is planned for 2018 to carry forward the initiative of learning and exchange of knowledge.
Advances in Computational Toxicology
This book provides a comprehensive review of both traditional and cutting-edge methodologies that are currently used in computational toxicology and specifically features its application in regulatory decision making. The authors from various government agencies such as FDA, NCATS and NIEHS industry, and academic institutes share their real-world experience and discuss most current practices in computational toxicology and potential applications in regulatory science. Among the topics covered are molecular modeling and molecular dynamics simulations, machine learning methods for toxicity analysis, network-based approaches for the assessment of drug toxicity and toxicogenomic analyses. Offering a valuable reference guide to computational toxicology and potential applications in regulatory science, this book will appeal to chemists, toxicologists, drug discovery and development researchers as well as to regulatory scientists, government reviewers and graduate students interested in this field.
Rebirth: Divine Arts of the North
A heaven-defying character! The legend that was created to defy the will of the heavens! What do you think you'll do when you have the talent to learn whatever you want, plus the limitless absorption of your internal energy with the Divine Art of Beiming? Scoundrel Lei Xing was hit by lightning after encountering the Seven Stars Orb once every ten thousand years. He accidentally teleported into the world that relied on the sky to make the Dragon Slayer's Note, but he was so lucky that he even managed to pass on to Chen You Liang. He envied the heaven-defying talent to death, and the unlimited absorption of the internal energy of the Divine Art of Beiming, to the point where it had fallen into the hands of the protagonist. All the brilliance in "Rebirth of the Heavenly Art of the Northern Dark" (Little Bamboo, new book, great support!) Pure top quality novels, YY to the home, YY to the grave!)
