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Epidermal Stem Cell Niche
  • Language: en
  • Pages: 232

Epidermal Stem Cell Niche

Advances in Stem Cells and Their Niches, Volume Three, comprises a compilation of the latest findings on our understanding of skin biology. It extends the current knowledge on skin stem cells and provides in-depth discussions on their unique settings, niches and properties. Chapters in this new release include The biophysical regulation of epidermal fate and function, Epidermal stem cell lineages, Hair shaft progenitors that create a niche for hair pigmentation, Dermal papilla cells control of hair follicle growth and pigmentation, Molecular mechanisms regulating the hair follicle niche, Dermal fibroblasts and their niches and interactions with epidermal stem cells. - Contains chapters written by international leaders in skin biology - Provides a unique compilation of the latest findings and technologies in basic and translational skin biology - Expands current knowledge on the regulation of skin stem cells as isolated entities, focusing on how skin stem cells and lineages of stem cells function in a coordinated manner - Provides illustrations and comprehensive analyses of each subject

Hair Follicle Regeneration
  • Language: en
  • Pages: 310

Hair Follicle Regeneration

This book aims to comprehensively review the current cell-based strategies under investigation to achieve the regeneration of human hair follicles. The unique capacity of the human hair follicle to self-renew explains why this complex “mini-organ” has always attracted so much interest as a model for researchers to study stem cell biology and regenerative medicine. The hair follicle is considered a main reservoir of cutaneous stem cells, containing several pools of epithelial, melanocyte, and mesenchymal stem cells involved in hair follicle self-regeneration and pigmentation. In addition, while some of the different follicular cell types contribute to hair shaft growth, others participate...

Point Particles to Capture Polarized Embryonic Cells & Cold Pools in the Atmosphere
  • Language: en
  • Pages: 319

Point Particles to Capture Polarized Embryonic Cells & Cold Pools in the Atmosphere

Part 1: How are the incredible diversity and robustness compatible with animal morphologies? Based on apical-basal and planar cell polarities’ ubiquity, I suggest a 3D mathematical model: Point particles represent cells having zero, one, or two unit-arrows representing polarities. I test the model abilities on preimplantation development, sea urchin gastrulation, mammalian neurulation, organoid folding, and tubulogenesis. I find that a minimal, versatile toolbox, including cellular polarities, captures the emergence of diverse and robust animal morphologies. Part 2: How are deep convective events spatially organized in the tropical atmosphere? Here, I test the importance of atmospheric cold pools for organizing convection. I suggest a 2D mathematical model: Points expand into circles representing cold pools. When circles meet, a convective event occurs, and a new circle forms. I find this model captures convective scale increase and initial stages of convective self-aggregation. The latter is crucial due to its link to tropical cyclogenesis.

Poetry in English and Metal Music
  • Language: en
  • Pages: 333

Poetry in English and Metal Music

Many metal songs incorporate poetry into their lyrics using a broad array of techniques, both textual and musical. This book develops a novel adaptation, appropriation, and quotation taxonomy that both expands our knowledge of how poetry is used in metal music and is useful for scholars across adaptation studies broadly. The text follows both a quantitative and a qualitative approach. It identifies 384 metal songs by 224 bands with intertextual ties to 146 poems written by fifty-one different poets, with a special focus on Edgar Allan Poe, John Milton's Paradise Lost and the work of WWI's War Poets. This analysis of transformational mechanisms allows poetry to find an afterlife in the form o...

Molecular Mechanisms and Signaling in Endothelial Cell Biology and Vascular Heterogeneity
  • Language: en
  • Pages: 332
Molecular Biology of the Cell
  • Language: en
  • Pages: 880

Molecular Biology of the Cell

  • Type: Book
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  • Published: 2007
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  • Publisher: Unknown

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MicroRNAs in Development
  • Language: en
  • Pages: 327

MicroRNAs in Development

This new volume in the Current topics in Developmental Biology series concentrates on MicroRNAs in Development. It includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA. With an international team of authors, this volume is a must-have addition for researchers and students alike. Concentrates on microRNAs in development Includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA With an international team of authors, this volume is a must-have addition for researchers and students alike

MicroRNAs: Key Regulators of Oncogenesis
  • Language: en
  • Pages: 449

MicroRNAs: Key Regulators of Oncogenesis

  • Type: Book
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  • Published: 2014-07-08
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  • Publisher: Springer

Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs have a crucial function in oncogenesis by regulating cell proliferation and apoptosis as oncogenes or tumor suppressors. The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in oncogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for cancer therapy by either inhibiting or augmenting their activity.

MicroRNAs in Medicine
  • Language: en
  • Pages: 702

MicroRNAs in Medicine

MicroRNAs in Medicine provides an access point into the current literature on microRNA for both scientists and clinicians, with an up-to-date look at what is happening in the emerging field of microRNAs and their relevance to medicine. Each chapter is a comprehensive review, with descriptions of the latest microRNA research written by international leaders in their field. Opening with an introduction to what microRNAs are and how they function, the book goes on to explore the role of microRNAs in normal physiological functions, infectious diseases, non-infectious diseases, cancer, circulating microRNAs as non-invasive biomarkers, and finally their potential as novel therapeutics. Including background information on the field as well as reviews of the latest research breakthroughs, MicroRNAs in Medicine is a one-stop source of information to satisfy the specialists and non-specialists alike, appealing to students, researchers, and clinicians interested in understanding the potential of microRNAs in medicine and research.