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NETosis 2: The Excitement Continues
NETosis, a form of cell death that manifests by the release of decondensed chromatin to the extracellular space, provides valuable insights into mechanisms and consequences of cellular demise. Because extracellular chromatin can immobilize microbes, the extended nucleohistone network was called a neutrophil extracellular trap (NET), and the process of chromatin release was proposed to serve an innate immune defense function. Extracellular chromatin NETs were initially observed in studies of neutrophils and are most prominent in these types of granulocytes. Subsequent studies showed that other granulocytes and, in a limited way, other cells of the innate immune response may also release nucle...
Debating the Past
This volume examines how the search for "cultural authenticity," the dispute over the past, and the role of "modernity" have been instrumental in building the regional musical culture of the Mantaro Valley, a central Peruvian region with about half a million inhabitants. How these people have addressed concerns over the loss of ancient traditions by restructuring colonial and pre-Hispanic traditions into new contexts and forms is explored. Covering private and public music making, along with ritual, ceremonial, and popular uses of music, Romero studies the interaction of music and identity. The book is concerned with a modern regional culture, situated and defined in the context of an emergent nation, which is struggling to build a distinct cultural identity and to recreate values.
Role of Neutrophils in Disease Pathogenesis
This book highlights the important role of neutrophils in health as well as in the pathogenesis of various diseases. Section 1 provides a general background information regarding the mechanisms and various triggers of neutrophil extracellular traps (NETs) formation and their role in various infectious and noninfectious diseases (such as postinjury inflammation). Section 2 provides recent evidence regarding the role of neutrophils in the pathogenesis as well as a therapeutic target for selected disease conditions such as periodontal diseases, rheumatoid arthritis, and cystic fibrosis. Section 3 describes the anti-inflammatory properties of neutrophils with focus regarding their role in graft versus host disease. This book provides a wider picture with regard to the importance of this immune cell type in various diseases with focus on one of its recently discovered properties, NETs. Therapeutic targets aimed to modulate neutrophil functions might provide novel approaches in the treatment of various diseases of infectious and noninfectious origin.
Platelets as Immune Cells in Physiology and Immunopathology
Are platelets cells? (Not everyone agrees, since they are non-nucleate). And if platelets are cells - which all specialists consider at the time being - are they immune cells? The issue that platelets participate in immunity is no longer debated; however, the issue that they are key cells in immunity is challenged. It has even been proposed a couple of years ago that platelets can present antigen to T-lymphocytes by using their HLA class I molecules. No one has the same functional definition of platelets. The ‘Frontiers Research Topic’- coordinators’ own view is that platelets are primarily repairing cells, what they do in deploying tools of physiological inflammation. This function is...
Revista Medicina
None
Hematologia
Hematologia
