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Molecular Autoimmunity
2004 marks the 100th anniversary of the first description of the autoimmune disease paroxysmal cold hemoglobinuria, a rare hemolytic disorder, by Julius Donath and Karl Landsteiner. After a century of research, the list of autoimmune diseases has become impressive. With a prevalence of approximately 5% of the world-wide population, these chronic, debilitating conditions affect almost every major organ of the body and, for reasons that remain unclear, are much more prevalent in woman than in men. Despite our rapidly expanding knowledge of the cellular and molecular pathways that govern a normal immune response, deciphering the precise etiology of autoimmune diseases remains an important chall...
Autoimmunity: Experimental Aspects
Combining principles of contemporary immunology with applications to immunopathology, this up-to-date volume documents new developments in the understanding of the origin of autoimmune diseases. Emphasized are cellular and molecular approaches in both organ-specific and systemic autoimmunity. A comprehensive bibliography, numerous illustrations, and tables make it an invaluable source of information for immunologists, rheumatologists, pathologists, dermatologists, and nephrologists.
The Epigenetics of Autoimmune Diseases
The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases. Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field. Specific coverage includes: How highly developed epigenetic mechanisms are involved in several aspects of normal immune regulation, in addition to maintaining immune tolerance to self-determinants. Specific epigenetic ...
Human B-cell Superantigens
Superantigens are a rapidly growing new class of ligands for human B-cells. The study of their interaction with lymphocytes provides insight into important mechanisms of the immune system. In this book, leading scientists survey the progress recently made in the identification, the nature, the structure of B-cell superantigens and their potential involvement in pathological conditions. It is the first book to bring together a comprehensive view of the recently described B-cell superantigens.
Proceedings of ICI Milan 2013
This Research Topic covers all of the major lectures and symposia addresses delivered by invited speakers at the 2013 International Congress in Immunology (ICI) at Milan, Italy, August 22-27, 2013.
Antibody Engineering Protocols
This comprehensive collection of recently developed methods for producing new antibody reagents by immunization and recombinant DNA techniques contains ready-to-use protocols that illuminate current areas of research on antibody structure, functions, and applications. The methods can be applied in basic immunological studies involving antibody specificity, catalysis, and evolution, and in the isolation of rare antibodies by phage display technology and the engineering of new antibodies by mutagenesis. They offer insight into new ways of developing clinically useful antibody reagents. Antibody Engineering Protocols constitutes a single-source volume for laboratory investigators who want to minimize extensive literature and methodology searches and to work productively in their fields with reproducible step-by-step protocols.
