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Therapeutic targeting of circulating tumor cells
There has been increased interest in circulating tumor cells (CTC), as a diagnostic readout of disease progression, and a tool for personalized medicine. The next generation of therapy for metastatic cancer may well involve neutralizing CTC as a means to prevent metastasis. In this topic we focus on recent research exploring this concept.
Cell'Cell Interactions
A versatile collection of readily reproducible cell-cell interaction assays for uncovering cellular interactions at the molecular level, both in vitro and in vivo. The protocols cover a diverse set of cell-cell interaction models in both normal and pathological states, are readily adaptable to nearly any cell type and organ system, and include primary data and outcome analysis. In addition, the protocols follow the successful Methods in Molecular BiologyTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
AACR 2016: Abstracts 2697-5293
The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 2697-5293 presented on April 19-20, 2016, at the AACR Annual Meeting.
AACR 2017 Proceedings: Abstracts 1-3062
The AACR Annual Meeting highlights the best cancer science and medicine from institutions all over the world. Attendees are invited to stretch their boundaries, form collaborations, attend sessions outside their own areas of expertise, and learn how to apply exciting new concepts, tools, and techniques to their own research. Part A contains abstracts 1-3062 accepted for the 2017 meeting.
AACR 2019 Proceedings: Abstracts 1-2748
American Association for Cancer Research 2019 Proceedings: Abstracts 1-2748 - Part A
Interaction between Hyaluronic Acid and Its Receptors (CD44, RHAMM) Regulates the Activity of Inflammation and Cancer
The biological outcome of Hyaluronan (also hyaluronic acid, abbreviated HA) interaction with its CD44 or RHAMM receptors recently attracted much attention within the scientific community owing to a Nature article by Tian X et al. (Nature 2013; 499:346-9). The article described a life span exceeding 30 years in naked mole rats, whereas the maximal lifespan of mice, to which the naked mole rat is related, is only 4 years. This observation is accompanied by the finding that the naked mole rat, in contrast to the mouse, does not develop spontaneous tumors during this exceptional longevity. The article provides evidence that interaction of long tissue HA (6000-12,000 kDa) of the naked mole rat wi...
American Fire: Love, Arson, and Life in a Vanishing Land
A New York Times Notable Book of the Year A Washington Post Notable Book of the Year One of Amazon’s 20 Best Books of the Year Named one of the Best Books of the Year by Buzzfeed, Bustle, NPR, NYLON, and Thrillist Finalist for the Goodreads Book Award (Nonfiction) Finalist for the Edgar Award (Best Fact Crime) A Book of the Month Club Selection A New York Times Book Review Editors’ Choice Selection “A brisk, captivating and expertly crafted reconstruction of a community living through a time of fear.... Masterful.” —Washington Post The arsons started on a cold November midnight and didn’t stop for months. Night after night, the people of Accomack County waited to see which buildi...
