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mTOR Inhibition for Cancer Therapy: Past, Present and Future
This book describes the challenges involved in developing mTOR inhibitors for cancer treatment, starting with an in-depth examination of their molecular mechanism of action, with emphasis on the class side-effects, efficacy and mechanisms of resistance, as well as on promising novel directions for their development, including novel compounds and rational combinations with other anti-neoplastic drugs. Over the last 10 years, inhibitors of mTOR have emerged as a major class of anticancer drugs. Two rapamycin analogs are currently approved for the treatment of renal cell carcinoma, and it is estimated that a variety of other tumor types could benefit from mTOR inhibition, with numerous clinical trials (including pivotal registration trials) already underway. Second-generation small-molecule inhibitors of the pathway have also shown promise in terms of their superior tolerability and efficacy and are undergoing extensive clinical evaluation, with an estimated 30+ compounds currently under evaluation.
AACR 2022 Proceedings: Part A Online-Only and April 10
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
Learning SQL on SQL Server 2005
Anyone who interacts with today's modern databases needs to know SQL (Structured Query Language), the standard language for generating, manipulating, and retrieving database information. In recent years, the dramatic rise in the popularity of relational databases and multi-user databases has fueled a healthy demand for application developers and others who can write SQL code efficiently and correctly. If you're new to databases, or need a SQL refresher, Learning SQL on SQL Server 2005 is an ideal step-by-step introduction to this database query tool, with everything you need for programming SQL using Microsoft's SQL Server 2005-one of the most powerful and popular database engines used today...
Perinnön varjo
Iäkäs Olivia Morrow saa tietää, että hänellä on enää kaksi viikkoa elinaikaa. Olivian on aika tehdä raskas päätös: paljastaako sukua varjostanut synkkä salaisuus seuraaville sukupolville vai viedäkö se mukanaan hautaan.
Cardio-Oncology
Cardio-Oncology: Principles, Prevention and Management is a clinical volume that focuses on the basic science of cardio-oncology, addresses cardiotoxicity as a consequence of cancer therapy, and discusses prevention, diagnosis and management of cardiovascular disease in patients with cancer. This comprehensive volume presents unique perspectives ranging from basic science to clinical medicine in the field of cardio-oncology. It would be a valuable resource for cardiologists, oncologists, internists, and pediatricians caring for patients with cancer who have cardiovascular risk factors, as well as for cardio-oncology researchers. Covers basic science of cardio-oncology to provide readers with the necessary background Addresses cardiotoxicity related to current cancer therapeutic modalities Discusses diagnostic and management approaches of patients with underlying cardiac risk factors as well as otherwise healthy cancer patients
Totuus Hallavan hevosen majatalosta
"Niin ylivoimaisesti kuin Christie jo hallitseekin WSOY:n hyvätasoista sarjaa, on hän tällä kerralla päässyt aivan erikoisluokkaan." S-a, Kansan Uutiset 1962 Tytöt tappelevat keskenään hysteerisen raivon vallassa ja syytävät toisilleen rumia sanoja. Vaaleaverikkö heittää ilmaan tukon toverinsa punaisia hiuksia virkavallan silmien edessä. Parin viikon kuluttua punatukkainen tyttö haudataan hiljaisuudessa. Pian tämän jälkeen isä Gorman saa kiireisen kutsun rouva Davisin kuolinvuoteen ääreen. Naisparka kertoo tarinan, ja pappi kolkataan jo kotimatkalla. Tässä kertomuksessa Christie irrotteli monin tavoin: voodoo-verhon ja mystiikan hämmentämää sattumien sarjaa selvit...
Kehän Titaanit
Kehän Titaanit on tarina showpainin uskomattomasta maailmasta. Kun suurin promootio Global Wrestling Federation on kärsimässä alamäkeä, itsenäiset promootiot ovat nauttimassa uutta valoisaa aikakautta internetin ansiota. Seitsemän uuden sukupolven nousevaa tähteä ottivat haasteen vastaan, tavoitteena voittaa promootion arvokkain mestaruus omaan haltuunsa. Vaikka parrasvalot ovat suunnattu kehälle, varjossa uhka odottaa oikeaa hetkeä iskeä uuden sivun showpainin renessanssille.
Alistuvia Naisia
Se koostuu seuraavista romaaneista: Alistuva Fantastic Girl Riisuutumispeli Alistuva Latinalainen Nainen Alistuvia Naisia on romaani, jolla on vahva BDSM-eroottinen sisältö, ja puolestaan uusi romaani, joka kuuluu Eroottinen Dominointi ja Alistuminen, sarja romaaneja, joissa on korkea romanttinen ja eroottinen BDSM-sisältö. (Kaikki hahmot ovat vähintään 18-vuotiaita) Huomautus kirjoittajalle: Erika Sanders on kansainvälisesti tunnettu, yli kahdellekymmenelle kielelle käännetty kirjailija, joka allekirjoittaa eroottisimmat kirjoituksensa, kaukana tavallisesta proosastaan, tyttönimellään.
Monica Morse’S Life
This book is about four different things The first thing is when I started going to school I drank my first cup of coffee before I went to school I even took coffee with me to school and kept it in my locker. The second thing is when my sisters graduate from high school and we all go on a trip together The third thing is I said a lot of funny things when I was a kid. The fourth thing is all my health problems that I listed in the book The fifth thing is my family and what all we did together
