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Leishmaniasis is a vector-borne, parasitic disease with tremendous variety in presentation, biology, and epidemiology. Any book on this disease must acknowledge the nearly impossible task of providing an exhaustive account of leishmaniasis simply because the epidemiology of the disease is so very complex. This book addresses some of this variety with chapters on the epidemiology of leishmaniasis in North Africa, Central America, and South America. The purpose of the book is not to specifically address diagnosis and treatment of the disease, but rather to provide a sample of the differing epidemiologies of leishmaniasis that occur due to variations in local habitats; the presence of different vectors, reservoirs, and agents; and the wide variety of cultures in which this disease occurs.
New edition exploring the mechanical features of biological cells for advanced undergraduate and graduate students in physics and biomedical engineering.
This volume presents information on both the basic and clinical aspects of sphingolipid-metabolizing enzymes in various cancers. The volume also includes discussions of the innovative techniques and approaches for quantitative analysis and imaging that could significantly impact the general understanding of this topic, and the potential benefit of targeting sphingolipid enzymes to develop novel cancer therapeutics. As well, the volume includes a critical examination of the specific pathways and pathobiologies associated with the altered regulation of sphingolipid metabolism as a contributor to the development and/or maintenance of pathological conditions such as cancer.
At first glance, roads seem like the simplest possible geotechnical structures. However, analysis of these structures runs up against complexities related to the intense stresses experienced by road surfaces, their intense interaction with climate, and the complicated behavior of the materials used in road construction. Modern mechanistic approaches to road design provide the tools capable of developing new technical solutions. However, use of these approaches requires deep understanding of the behavior of constituent materials and their interaction with water and heat which has recently been acquired thanks to advances in geotechnical engineering. The author comprehensively describes and ex...
This thought-provoking book explores the emerging construction of a customary law of peace in Latin America and the developing jurisprudence of the Inter-American Court of Human Rights. It traces the evolution of peace as both an end and a means: from a negative form, i.e. the absence of violence, to a positive form that encompasses equality, non-discrimination and social justice, including gendered perspectives on peace.
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At first glance, roads seem like the simplest possible geotechnical structures. However, analysis of these structures runs up against complexities related to the intense stresses experienced by road surfaces, their intense interaction with climate, and the complicated behavior of the materials used in road construction. Modern mechanistic approaches to road design provide the tools capable of developing new technical solutions. However, use of these approaches requires deep understanding of the behavior of constituent materials and their interaction with water and heat which has recently been acquired thanks to advances in geotechnical engineering. The author comprehensively describes and ex...