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Tutorials in Biostatistics, Tutorials in Biostatistics
The Tutorials in Biostatistics have become a very popular feature of the prestigious Wiley journal, Statistics in Medicine (SIM). The introductory style and practical focus make them accessible to a wide audience including medical practitioners with limited statistical knowledge. This book represents the second of two volumes presenting the best tutorials published in SIM, focusing on statistical modeling of complex data. Topics include clustered data, hierarchical models, mixed models, genetic modeling, and meta-analysis. Each tutorial is focused on a medical problem, has been fully peer-reviewed and edited, and is authored by leading researchers in biostatistics. Many articles include an appendix on the latest developments since publication in the journal and additional references. This will appeal to statisticians working in medical research, as well as statistically-minded clinicians, biologists, epidemiologists and geneticists. It will also appeal to graduate students of biostatistics.
Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research
Accurate sample size calculation ensures that clinical studies have adequate power to detect clinically meaningful effects. This results in the efficient use of resources and avoids exposing a disproportionate number of patients to experimental treatments caused by an overpowered study. Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research explains how to determine sample size for studies with correlated outcomes, which are widely implemented in medical, epidemiological, and behavioral studies. The book focuses on issues specific to the two types of correlated outcomes: longitudinal and clustered. For clustered studies, the authors provide sample size formulas...
A Mixture Model Approach to Empirical Bayes Testing and Estimation
Many modern statistical problems require making similar decisions or estimates for many different entities. For example, we may ask whether each of 10,000 genes is associated with some disease, or try to measure the degree to which each is associated with the disease. As in this example, the entities can often be divided into a vast majority of "null" objects and a small minority of interesting ones. Empirical Bayes is a useful technique for such situations, but finding the right empirical Bayes method for each problem can be difficult. Mixture models, however, provide an easy and effective way to apply empirical Bayes. This thesis motivates mixture models by analyzing a simple high-dimensional problem, and shows their practical use by applying them to detecting single nucleotide polymorphisms.
Quantitative Evaluation of Safety in Drug Development
State-of-the-Art Methods for Drug Safety Assessment Responding to the increased scrutiny of drug safety in recent years, Quantitative Evaluation of Safety in Drug Development: Design, Analysis and Reporting explains design, monitoring, analysis, and reporting issues for both clinical trials and observational studies in biopharmaceutical product development. It presents the latest statistical methods for drug safety assessment. The book’s three sections focus on study design, safety monitoring, and data evaluation/analysis. The book addresses key challenges across regulatory agencies, industry, and academia. It discusses quantitative approaches to safety evaluation and risk management in drug development, covering Bayesian methods, effective safety graphics, and risk-benefit evaluation. Written by a team of experienced leaders, this book brings the most advanced knowledge and statistical methods of drug safety to the statistical, clinical, and safety community. It shares best practices and stimulates further research and methodology development in the drug safety area.
Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials
Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials is the first book focused on the application of generalized linear mixed models and its related models in the statistical design and analysis of repeated measures from randomized controlled trials. The author introduces a new repeated measures design called S:T design combined with mixed models as a practical and useful framework of parallel group RCT design because of easy handling of missing data and sample size reduction. The book emphasizes practical, rather than theoretical, aspects of statistical analyses and the interpretation of results. It includes chapters in which the author describes some old-fashioned analysis designs that have been in the literature and compares the results with those obtained from the corresponding mixed models. The book will be of interest to biostatisticians, researchers, and graduate students in the medical and health sciences who are involved in clinical trials. Author Website:Data sets and programs used in the book are available at http://www.medstat.jp/downloadrepeatedcrc.html
Series Approximation Methods in Statistics
This book was originally compiled for a course I taught at the University of Rochester in the fall of 1991, and is intended to give advanced graduate students in statistics an introduction to Edgeworth and saddlepoint approximations, and related techniques. Many other authors have also written monographs on this subject, and so this work is narrowly focused on two areas not recently discussed in theoretical text books. These areas are, first, a rigorous consideration of Edgeworth and saddlepoint expansion limit theorems, and second, a survey of the more recent developments in the field. In presenting expansion limit theorems I have drawn heavily 011 notation of McCullagh (1987) and on the th...
What's Wrong with Fat?
What's Wrong with Fat? examines the social implications of understanding fatness as a medical health risk, disease, and epidemic. Examining the ways in which debates over fatness have developed, Abigail Saguy argues that the obesity crisis literally makes us fat, intensifies negative body image, and justifies weight-based discrimination.
Research Abstract In Physical Education And Sport Science (2 Vols.)
The book covers all the dimensions of Physical Education and Sports Sciences through nine major branches namely, Anthropometry, Biomechanics, Endurance, Flexibility, Hormones, Psychological Variables, Rehabilitation, Speed and Yoga. Each branch contains minimum fifty research abstracts. The abstracts contain introduction, methodology, results and conclusions. The author did not manipulate anything in the abstracts, since it may create big problem to him. A researcher can use it for his/her thesis as a review or even he/she may contact the corresponding author for seeking help in their respective research. The author has given the abstracts with variable index, thus, a reader can choose variables or find a particular variable without undue strain. The book contains the chapters: 1. Anthropometric Variables, 2. Biomechanical variables, 3. Endurance variables, 4. Flexibility variables, 5. Harmones variables, 6. Psychological variables, 7. Rehabilitation variables, 8. Speed variables, 9. Yoga variables.
