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Amyotrophic Lateral Sclerosis
A flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors trigger neuromuscular dysfunction is critical for developing more effective ALS therapeutics. The ‘gain-of-toxicity’ or ‘loss-of-function’ of these etiological factors is a key question. Recent studies on the imbalance in genome damage versus repair have opened avenues for potential DNA repair-based therapeutics. This book highlights emerging science in the area of ALS and discusses key approaches and mechanisms essential for developing a cure for ALS.
DNA Repair
This book offers a collection of chapters addressing different studies on DNA repair from a cellular and molecular point of view. The various contributions highlight the vastness of DNA repair process and the need for a deeper understanding. To this end, the recent considerations here presented can be a cue for scientists and students working on, or interested in, the subject of DNA repair in human cells. This book may suggest to readers new avenues of interplay between different kinds of DNA damage and cellular response for maintaining nuclear and mitochondrial genomic stability.
Mechanisms of DNA Repair
Mechanisms of DNA Repair.
Neurodegeneration Nanotechnology in Neurodegenerative Diseases
This book stems from the urgent necessity to address neurodegenerative diseases, which are among the most severe health challenges currently confronting society. Neurodegenerative diseases have become a major threat to public health in recent years, impacting millions of people globally and creating a substantial strain on healthcare systems and society as a whole. Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis are examples of these diseases. This book offers a thorough survey of the latest developments in this rapidly growing field. This book is targeted towards a wide range of readers, including academics, researchers, medical professionals, students, policy makers, and anybody else who is interested in the convergence of neuroscience, nanotechnology, and healthcare. Irrespective of one's familiarity with the subject, this book provides motivation and insightful information to bolster our group's endeavors in combating these debilitating diseases.
Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease
This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heav...
Base Excision Repair Pathway
This detailed volume provides a comprehensive set of experimental protocols and useful strategies to examine the repair of damaged bases via the Base Excision Repair (BER) pathway in vitro and in cells. Beginning with multiple molecular and cellular techniques to examine the excision of damaged bases from double-stranded DNA or DNA wrapped in a nucleosome, the book continues with sections covering procedures to detect and quantify the damaged bases, protein DNA crosslinks, and double-strand breaks, experimental procedures to identify DNA repair protein interactome by conventional tandem affinity purification followed by mass spectroscopy analysis, as well as the analysis of genome-wide bindi...
Comprehensive Inorganic Chemistry II
Comprehensive Inorganic Chemistry II, Nine Volume Set reviews and examines topics of relevance to today’s inorganic chemists. Covering more interdisciplinary and high impact areas, Comprehensive Inorganic Chemistry II includes biological inorganic chemistry, solid state chemistry, materials chemistry, and nanoscience. The work is designed to follow on, with a different viewpoint and format, from our 1973 work, Comprehensive Inorganic Chemistry, edited by Bailar, Emeléus, Nyholm, and Trotman-Dickenson, which has received over 2,000 citations. The new work will also complement other recent Elsevier works in this area, Comprehensive Coordination Chemistry and Comprehensive Organometallic Che...
