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Chemotherapy is one of the major treatment options for cancer patients; however, the efficacy of chemotherapeutic management of cancer is severely limited by multidrug resistance, in that cancer cells become simultaneously resistant to many structurally and mechanistically unrelated drugs. In the past three decades, a number of mechanisms by which cancer cells acquire multidrug resistance have been discovered. In addition, the development of agents or strategies to overcome resistance has been the subject of intense study. This book contains comprehensive and up-to-date reviews of multidrug resistance mechanisms, from over-expression of ATP-binding cassette drug transporters such as P-glycop...
This book discusses selected current issues in the field of public finance and public administration. These current issues include budget right, global public goods, financial reporting, control of the activities, robot tax, arms trade, tax expenditures and mandatory private pension system, public and private partnerships, fiscal space, ethics, governance, urban safety and metropolitan municipality. For this reason, the book is capable of appealing to everyone interested in these fields. It will also contribute to researchers who want to improve themselves in public finance and public administration.
The complete guide to alternative investments, from experts working with CFA Institute Alternative Investments is the definitive guide to understanding non-traditional asset classes. Alternatives are a disparate group of investments that are distinguished from long-only, publicly traded investments in stocks, bonds, and cash (often referred to as traditional investments). Alternative investments include real estate, commodities, infrastructure, and other non-traditional investments such as private equity or debt and hedge funds. They are attractive to investors because of the potential for portfolio diversification resulting in a higher risk-adjusted return for the portfolio. Alternative Inv...
After Philosophy provides an excellent framework for understanding the most important strains of current philosophical work in North America, England, France, and Germany. The selections from the work of fourteen contemporary philosophers not only display the multiplicity of approaches being pursued since the breakup of any consensus on what philosophy is, but also help to clarify this proliferation of views and to spell out today's basic options for doing, or not doing, philosophy today. With a general introduction delineating what is in dispute between the different parties to the end-of-philosophy debates, brief introductions to the thought of each author, and suggestions for further read...
Wide-ranging, erudite and stimulating, this thought-provoking volume describes the birth and development of one of the most important basic ideas of our civilization: progress, or the concept that humanity is advancing in a definite and desirable direction. Throughout, Bury examines the contributions of Darwin, Descartes, Voltaire, Locke, and other important thinkers.
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This book addresses the application of nanotechnology to cosmetics. Edited by three respected experts in the field, the book begins with a general overview of the science behind cosmetics and skin care today, and of the status quo of nanotechnology in cosmetics. Subsequent chapters provide detailed information on the different nanoparticles currently used in cosmetics; the production and characterization of nanoparticles and nanocosmetics; and regulatory, safety and commercialization aspects. Given its scope, the book offers an indispensable guide for scientists in academia and industry, technicians and students, as well as a useful resource for decision-makers in the field and consumer organizations. Chapter 6 of this book is available open access under a CC BY 4.0 licence at link.springer.com.
This policy guidance outlines a number of steps to be considered when building capacity for greening national development planning, national budgetary processes and key economic sector strategies.
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