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Revised and updated, this Second Edition of a classic text describes and evaluates--in greater detail--the most recent practical applications of flow cytometry technique to basic cellular biological investigations and clinical research on human neoplasms. Ideal for the experienced researcher as well as the novice, this informative book offers state-of-the-art reviews of all aspects of flow cytometry. New articles highlight investigations of higher plants, the flow cytometry of microorganisms, and measurements of intracellular ionized calcium and membrane potential--illustrating techniques of specimen preparation, measurement and analysis for each. New chapters examine applications of flow cytometry to medical genetics, genetic toxicology, and ultrasensitive analysis of molecules in solution. The Second Edition goes beyond the traditional analysis of DNA histograms with BrdU incorporation and DNA denaturability to identify and analyze the cell cycle more precisely. New or rewritten chapters discuss the importance of flow cytometry for measurements of nucleic acids, chromatin, and DNA and cover the cytometry of sperm and the cytopathic effects of viruses.
The most influential and frequently cited pathology classic is now in its Fifth Edition, with thoroughly revised chapters and over 3,000 brand-new full-color illustrations. This two-volume work provides comprehensive, current information on the principles and techniques of cytopathology and the cytologic evaluation of benign and malignant disorders at every anatomic site. This edition provides greatly expanded coverage of the interpretation of aspirated cell samples. Innovations in the practice of cytopathology and data on molecular biology and cytogenetics have been incorporated into the organ system chapters. This edition also has a greater focus on avoiding diagnostic errors. A bound-in image bank DVD is included in this edition.
The most influential and frequently cited pathology classic is now in its Fifth Edition, with thoroughly revised chapters and over 3,000 brand-new full-color illustrations. This two-volume work provides comprehensive, current information on the principles and techniques of cytopathology and the cytologic evaluation of benign and malignant disorders at every anatomic site. This edition provides greatly expanded coverage of the interpretation of aspirated cell samples. Innovations in the practice of cytopathology and data on molecular biology and cytogenetics have been incorporated into the orga.
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In an invigorating comparative and interdisciplinary reconsideration of the role of different types of medical counting, this wide-ranging bilingual volume takes us from the mortality tables of the eighteenth century to the movement for evidence-based medicine in our own day. Culled from the proceedings of La quantification dans les sciences medicales et de la sante: perspective historique held at the Musee Claude-Bernard in France in 2002, Body Counts moves beyond the usual emphasis on public health and clinical medicine to include the central role of numbers in laboratory work and medical instrumentation. Body Counts provides an innovative, historical, and sociological account of the funct...