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Phospholipases in Physiology and Pathology
Phospholipases in Physiology and Pathology presents a comprehensive overview on the physiology and pathology of phospholipases. This seven-volume set considers the biochemical and molecular mechanisms of normal and abnormal cell function upon dysregulation of phospholipases in different diseases. Volumes cover signal transduction mechanisms, implications in cancer, infectious diseases, neural diseases, cardiovascular diseases and other diseases, implications in inflammation, apoptosis, gene expression and non-coding RNAs, the role of natural and synthetic compounds, and stem cell therapies, nanotechnology-based therapies, and more. Together, these volumes give researchers critical insight on the mechanistic and therapeutic aspects of phospholipases. - Discusses the biochemical and molecular mechanisms of normal and abnormal cell function in different disease processes - Covers a wide range of basic and translational research appropriate for scientists engaged in studying the regulation of phospholipases from interdisciplinary perspectives - Features state-of-the-art chapter contributions from international leaders in the field
Genetic Programming Theory and Practice XIX
This book brings together some of the most impactful researchers in the field of Genetic Programming (GP), each one working on unique and interesting intersections of theoretical development and practical applications of this evolutionary-based machine learning paradigm. Topics of particular interest for this year ́s book include powerful modeling techniques through GP-based symbolic regression, novel selection mechanisms that help guide the evolutionary process, modular approaches to GP, and applications in cybersecurity, biomedicine and program synthesis, as well as papers by practitioner of GP that focus on usability and real-world results. In summary, readers will get a glimpse of the current state of the art in GP research.
Mobile TV: Customizing Content and Experience
Developing usable, useful, and appealing solutions for the customer or user experience requires customization according to specific users' needs amidst frequently changing physical and social environments. Complex design problems like these require interdisciplinary perspectives that cover software functionality, human interaction and communication experiences, and perceived value. After defining and summarizing current research and development, this book focuses on Mobile TV experience in everyday life, innovative conceptual and participatory design methods, contextual analysis methods, social context for interactive multimedia systems, advanced interaction with mobile digital content, and ...
Agriculture in Mediterranean Europe
This volume illustrates and deepens the understanding of current agrarian dynamics developing in Mediterranean countries in the light of recent theoretical contributions. The book compiles and analyses a set of Mediterranean case studies that show the range of transformations shaping contemporary agriculture in Southern Europe
Using Stress-Based Animal Models to Understand the Mechanisms Underlying Psychiatric and Somatic Disorders
Chronic or repeated stress, particularly psychosocial stress, is an acknowledged risk factor for numerous affective and somatic disorders in modern societies. Thus, there is substantial evidence showing that chronic stress can increase the likelihood of major depressive disorder and anxiety disorders, as well as cardiovascular diseases, irritable bowel syndrome and pain syndromes, to name but a few, in vulnerable individuals. Although a number of pharmacological agents are available to treat such stress-related disorders, many patients do not respond to them, and those who do often report a number of side effects. Therefore, a major emphasis in modern basic research is to uncover the underly...
The Next Generation in Membrane Protein Structure Determination
This book reviews current techniques used in membrane protein structural biology, with a strong focus on practical issues. The study of membrane protein structures not only provides a basic understanding of life at the molecular level but also helps in the rational and targeted design of new drugs with reduced side effects. Today, about 60% of the commercially available drugs target membrane proteins and it is estimated that nearly 30% of proteins encoded in the human genome are membrane proteins. In recent years much effort has been put towards innovative developments to overcome the numerous obstacles associated with the structure determination of membrane proteins. This book reviews a var...
