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Molecular and Functional Models in Neuropsychiatry
The development of more effective treatments for neuropsychiatric disorders requires scientific progress on a broad front. Animal models have a vital role to play in advancing the field. When deployed in conjunction with detailed study of these diseases in man they bring the power to make controlled experimental interventions which allow the functional consequences of genetic variations and polymorphisms to be understood in terms of their cellular, systems and behavioural effects. Further, they provide a means by which complex cognitive and behavioural phenomena may be dissected and understood. Finally, they provide a bridge to understanding the effects of drugs on the functioning of the central nervous system, thereby improving our understanding of the actions of those drugs in man.
Dialectics, Dogmas, and Dissent
Germany underwent two periods of dictatorial repression in the twentieth century, first under Hitler and the Nazis in the late 1930s and early 1940s and then under the communist German Democratic Republic from 1945 until the Berlin Wall fell in 1989. The abuses of human rights under the Nazis are well known and now abundantly documented. The abuses that occurred during the period of the GDR, however, are not so well known and are poorly documented. Through his interviews with survivors of GDR repression, John Rodden seeks to add to the history of this dark period. He reveals the many different ways in which ordinary people suffered at the hands of a brutal regime and its secret police enforcers, the Stasi. Some presented here are heroes; some are survivors, including those who played along to get along. As one teacher who conformed to stay safe admitted to Rodden, &“It was a nation that, by cutting us off from the truth, made cowards of us all.&”
The Genetics of Cancer
Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology. - Clonal evolution of the metastasis phenotype - Cell Cycle regulation - Apoptosis in tumour growth and metastasis - Angiogenesis in cancer - Cell surface glycoproteins and their receptors - Proteinases and their inhibitors in cancer invasion - Oncogenes and cancer metastasis - Developmental genes - Tumour suppressor genes - Metastasis suppressor genes - Dominant metastasis-associated genes
Official Congressional Directory
Includes maps of the U.S. Congressional districts.
Multicultural Odysseys
We are currently witnessing the global diffusion of multiculturalism, both as a political discourse and as a set of international legal norms. States today are under increasing international scrutiny regarding their treatment of ethnocultural groups, and are expected to meet evolving international standards regarding the rights of indigenous peoples, national minorities, and immigrants. This phenomenon represents a veritable revolution in international relations, yet has received little public or scholarly attention. In this book, Kymlicka examines the factors underlying this change, and the challenges it raises. Against those critics who argue that multiculturalism is a threat to universal ...
The Brain as a Drug Target
The brain is protected by the blood-brain barrier and this barrier prevents many drugs from entering the brain. This volume discusses various drug delivery and targeting strategies that are being developed to enhance the transport and distribution of drugs into the brain. Discusses new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields
