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This book presents the proceedings of TE2022, the 29th ISTE International Conference on Transdisciplinary Engineering, held at the Massachusetts Institute of Technology in Cambridge, United States, from 5 – 8 July 2022. Transdisciplinary engineering is the exchange of knowledge in the context of an innovation, in product, process, organisation or social environment. ISTE aims to explore and promote the evolution of engineering to incorporate transdisciplinary practices in which the exchange of different types of knowledge from a diverse range of disciplines is fundamental. The theme for the TE2022 conference is the future of engineering, and the 75 papers included here, which have all undergone a rigorous peer-review process, cover a wide range of topics and are grouped under 10 headings: Requirements, Knowledge and Architecture in Engineering; Case Studies; Energy, Environment, and Sustainability; Engineering Teamwork; Digital Engineering; imulation, Optimization, and Analytics; Manufacturing; Policy, Decisions, and Innovation; Engineering Education; Research on TE. The book will be of interest to all those working in the field of engineering today.
An up-to-date guide for using massive amounts of data and novel technologies to design, build, and maintain better systems engineering Systems Engineering in the Fourth Industrial Revolution: Big Data, Novel Technologies, and Modern Systems Engineering offers a guide to the recent changes in systems engineering prompted by the current challenging and innovative industrial environment called the Fourth Industrial Revolution—INDUSTRY 4.0. This book contains advanced models, innovative practices, and state-of-the-art research findings on systems engineering. The contributors, an international panel of experts on the topic, explore the key elements in systems engineering that have shifted towa...
Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.
This book details the foundations, new developments and methods, applications, and current challenges of systems engineering (SE). It provides key insights into SE as a concept and as an approach based on the holistic view on the entire lifecycle (requirements, design, production, and exploitation) of complex engineering systems, such as spacecraft, aircraft, power plants, and ships. Written by leading international experts, the book describes the achievements of the holistic, transdisciplinary approach of SE as state of the art both in research and practice using case study examples from originating at universities and companies such as Airbus, BAE Systems, BMW, Boeing, and COMAC. The reader obtains a comprehensive insight into the still existing challenges of the concept of SE today and the various forms in which SE is applied in a variety of areas.
Knowledge-intensive product realization implies embedded intelligence; meaning that if both theoretical and practical knowledge and understanding of a subject is integrated into the design and production processes of products, this will significantly increase added value. This book presents papers accepted for the 9th Swedish Production Symposium (SPS2020), hosted by the School of Engineering, Jönköping University, Sweden, and held online on 7 & 8 October 2020 because of restrictions due to the Corona virus pandemic. The subtitle of the conference was Knowledge Intensive Product Realization in Co-Operation for Future Sustainable Competitiveness. The book contains the 57 papers accepted for...
No one discipline or person can encompass all the knowledge necessary to solve complex, ill-defined problems, or problems for which a solution is not immediately obvious. The concept of Concurrent Engineering (CE) – interdisciplinary, but with an engineering focus – was developed to increase the efficiency and effectiveness of the Product Creation Process (PCP) by conducting different phases of a product’s life concurrently. Transdisciplinary Engineering has transcended CE, emphasizing the crucial importance of interdisciplinary openness and collaboration. This book presents the proceedings of the 28th ISTE International Conference on Transdisciplinary Engineering (TE2021). Held online...
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Transdisciplinary engineering transcends other inter- and multi-disciplinary ways of working, such as Concurrent Engineering (CE). In particular, transdisciplinary processes are aimed at solving complex, ill-defined problems, or problems for which the solution is not immediately obvious. No one discipline or single person can provide sufficient knowledge to solve such problems, so collaboration is essential. This book presents the proceedings of the 27th ISTE International Conference on Transdisciplinary Engineering, organized by Warsaw University of Technology, Poland, from 1-10 July 2020. ISTE2020 was the first of this conference series to be held virtually, due to the COVID-19 restriction...
Enterprise Architecture, Integration, and Interoperability and the Networked enterprise have become the theme of many conferences in the past few years. These conferences were organised by IFIP TC5 with the support of its two working groups: WG 5. 12 (Architectures for Enterprise Integration) and WG 5. 8 (Enterprise Interoperability), both concerned with aspects of the topic: how is it possible to architect and implement businesses that are flexible and able to change, to interact, and use one another’s s- vices in a dynamic manner for the purpose of (joint) value creation. The original qu- tion of enterprise integration in the 1980s was: how can we achieve and integrate - formation and ma...